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CHAC1 Antibody (OABF01753-100UL)

CHAC1 Antibody (OABF01753-100UL)

Item no.	OABF01753
Manufacturer	AVIVA Systems Biology
Amount	100 ul
Category	Oncology Neuroscience Targets for Rodent Neurosciences Aging & Neurological Disorders Neural Signaling Antibodies By Cell Type Hematology Leukemia Sarcoma Flow Cytometry Immunohistochemistry Western Blot ELISA Immunofluorescence Immunocytochemistry Primary Antibodies Immunostaining Immunochemistry
Type	Antibody Polyclonal
Format	Liquid
Applications	WB, FC, IF, IHC, ICC, ELISA
Specific against	Human (Homo sapiens), Mouse (Murine, Mus musculus), Rat (Rattus norvegicus), Rabbit (Oryctolagus cuniculus), Dog (Canine, Canis lupus familiaris), Pig (Porcine, Sus scrofa domesticus), Cattle (Bovine)
Host	Rabbit
Isotype	IgG
Conjugate/Tag	Unconjugated
ECLASS 10.1	32160702
ECLASS 11.0	32160702
UNSPSC	12352203
Alias	blocks Notch protein;botch;Cation transport regulator-like protein 1;ChaC,cation transport regulator homolog 1;ChaC,cation transport regulator-like 1;gamma-GCG 1;gamma-GCT acting on glutathione homolog 1;glutathione-specific gamma-glutamylcyclotransferase 1.
Shipping Condition	Cool pack
Available
Manufacturer - Type	Polyclonal Antibody
Manufacturer - Applications	Enzyme-linked immunosorbent assay\|Flow cytometry\|Immunocytochemistry\|Immunofluorescence\|Immunohistochemistry-Frozen\|Immunohistochemistry-Paraffin\|Western blot
Manufacturer - Category	Root Catalog/Products/Polyclonal Antibodies, Root Catalog/Products/Primary Antibodies
Shipping Temperature	Wet Ice
Manufacturer - Application Additional Information	WB: 1:100~1000 IHC-P: 1:100~500 Fluorescent-IHC: 1:50~200
Gene symbol	CHAC1
Gene Fullname	ChaC glutathione specific gamma-glutamylcyclotransferase 1
Product format	Liquid Aqueous buffered solution containing 1% BSA, 50% glycerol and 0.09% sodium azide.
Reconstitution and storage	-20°C
Description of target	Catalyzes the cleavage of glutathione into 5-oxo-L-proline and a Cys-Gly dipeptide. Acts specifically on glutathione, but not on other gamma-glutamyl peptides (PubMed:27913623). Glutathione depletion is an important factor for apoptosis initiation and execution. Acts as a pro-apoptotic component of the unfolded protein response pathway by mediating the pro-apoptotic effects of the ATF4-ATF3-DDIT3/CHOP cascade (PubMed:19109178). Negative regulator of Notch signaling pathway involved in embryonic neurogenesis: acts by inhibiting Notch cleavage by furin, maintaining Notch in an immature inactive form, thereby promoting neurogenesis in embryos (PubMed:22445366).
Protein name	Glutathione-specific gamma-glutamylcyclotransferase 1
Clonality	Polyclonal
Purification	Protein A Purified
Immunogen	KLH conjugated synthetic peptide derived from human CHAC1
Concentration	1 ug/ul

Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.

All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.

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Amount: 100 ul

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Delivery expected until 12/25/2025

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