« Back
Home /
THOC1 Antibody

THOC1 Antibody

Item no.	OACA02430
Manufacturer	AVIVA Systems Biology
Amount	100 ul
Category	Antibodies Immunohistochemistry Immunoprecipitation Western Blot ELISA Primary Antibodies CHiP Immunostaining
Type	Antibody Polyclonal
Format	Liquid
Applications	WB, IHC, ELISA, CHIP
Specific against	Human (Homo sapiens), Mouse (Murine, Mus musculus)
Host	Rabbit
Isotype	IgG
Conjugate/Tag	Unconjugated
Citations	[1] The death domain protein p84N5, but not the short isoform p84N5s, is cell cycle-regulated and shuttles between the nucleus and the cytoplasm. Gasparri F., Sola F., Locatelli G., Muzio M.FEBS Lett. 574:13-19 (2004). [2] Complete sequencing and characterization of 21,243 full-length human cDNAs. Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. Sugano S.Nat. Genet. 36:40-45 (2004). [3] The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). The MGC Project TeamGenome Res. 14:2121-2127 (2004).
ECLASS 10.1	32160702
ECLASS 11.0	32160702
UNSPSC	12352203
Alias	HPR1;hTREX84;nuclear matrix protein p84;P84;P84N5;THO complex subunit 1;tho1.
Shipping Condition	Cool pack
Available
Manufacturer - Type	Polyclonal Antibody
Manufacturer - Category	Root Catalog/Products/Polyclonal Antibodies, Root Catalog/Products/Primary Antibodies
Shipping Temperature	Wet Ice
Molecular Weight	76 kDa
Application Data	WB:1:500-2000, IHC:1:20-1:200
Gene symbol	THOC1
Gene Fullname	THO complex 1
Protein size	657
Product format	Liquid
Reconstitution and storage	-20°C or -80°C
Description of target	Required for efficient export of polyadenylated RNA. Acts as component of the THO subcomplex of the TREX complex which is thought to couple mRNA transcription, processing and nuclear export, and which specifically associates with spliced mRNA and not with unspliced pre-mRNA. TREX is recruited to spliced mRNAs by a transcription-independent mechanism, binds to mRNA upstream of the exon-junction complex (EJC) and is recruited in a splicing- and cap-dependent manner to a region near the 5' end of the mRNA where it functions in mRNA export to the cytoplasm via the TAP/NFX1 pathway. The TREX complex is essential for the export of Kaposi's sarcoma-associated herpesvirus (KSHV) intronless mRNAs and infectious virus production. Regulates transcriptional elongation of a subset of genes. Involved in genome stability by preventing co-transcriptional R-loop formation.
Nucleotide accession_num	NM_005131.2
Protein accession_num	NP_005122.2
Protein name	THO complex subunit 1
Clonality	Polyclonal
Purification	Affinity Purified
Immunogen	Recombinant Human THO complex subunit 1 protein (428-657AA)
Homology	Human, Mouse
Manufacturer - Specificity	Human
Formulation	Provided in PBS, pH 7.3, 50% Glycerol, 0.02% Sodium Azide

Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.

All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.

Request Data Sheet

OACA02430-datasheet.pdf

Request safety datasheet

Simple Order Order Subscription

Amount: 100 ul

available

Delivery expected until 10/30/2025

Express Delivery: Save 2 days

Compare

Add to wishlist

Get an offer