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CBX5 Antibody

CBX5 Antibody

Item no.	OACA02704-100UG
Manufacturer	AVIVA Systems Biology
Amount	100 ug
Category	Oncology Antibodies By Cell Type Melanoma Immunohistochemistry Immunoprecipitation Western Blot ELISA Immunofluorescence Primary Antibodies CHiP Immunostaining
Type	Antibody Polyclonal
Format	Liquid
Applications	WB, IHC, ELISA
Specific against	Human (Homo sapiens)
Host	Rabbit
Isotype	IgG
Conjugate/Tag	Unconjugated
Purity	>95%
Citations	[1]"A conserved Mis12 centromere complex is linked to heterochromatic HP1 and outer kinetochore protein Zwint-1."Obuse C., Iwasaki O., Kiyomitsu T., Goshima G., Toyoda Y., Yanagida M.Nat. Cell Biol. 6:1135-1141(2004). [2]"The mammalian heterochromatin protein 1 binds diverse nuclear proteins through a common motif that targets the chromoshadow domain." Lechner M.S., Schultz D.C., Negorev D., Maul G.G., Rauscher F.J. III Biochem. Biophys. Res. Commun. 331:929-937(2005). [3]"Dissociation of heterochromatin protein 1 from lamin B receptor induced by human polyomavirus agnoprotein: role in nuclear egress of viral particles." Okada Y., Suzuki T., Sunden Y., Orba Y., Kose S., Imamoto N., Takahashi H., Tanaka S., Hall W.W., Nagashima K., Sawa H.EMBO Rep. 6:452-457(2005).
ECLASS 10.1	32160702
ECLASS 11.0	32160702
UNSPSC	12352203
Alias	antigen p25;chromobox homolog 5 (HP1 alpha homolog,Drosophila);chromobox protein homolog 5;epididymis luminal protein 25;HEL25;heterochromatin protein 1 homolog alpha;heterochromatin protein 1-alpha;HP1;HP1 alpha homolog;HP1A;HP1-ALPHA;HP1Hs alpha.
Available
Manufacturer - Type	Polyclonal Antibody
Manufacturer - Category	Root Catalog/Products/Polyclonal Antibodies, Root Catalog/Products/Primary Antibodies
Gene symbol	CBX5
Gene Fullname	chromobox 5
Product format	Liquid
Reconstitution and storage	-20°C or -80°C
Description of target	Component of heterochromatin that recognizes and binds histone H3 tails methylated at 'Lys-9' (H3K9me), leading to epigenetic repression. In contrast, it is excluded from chromatin when 'Tyr-41' of histone H3 is phosphorylated (H3Y41ph). Can interact with lamin-B receptor (LBR). This interaction can contribute to the association of the heterochromatin with the inner nuclear membrane. Involved in the formation of functional kinetochore through interaction with MIS12 complex proteins.
Nucleotide accession_num	NM_001127321
Protein accession_num	NP_001120793
Protein name	Chromobox protein homolog 5
Clonality	Polyclonal
Purification	Protein G Purified
Immunogen	Recombinant Human Chromobox protein homolog 5 protein (1-191AA)

Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.

All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.

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Amount: 100 ug

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Delivery expected until 10/30/2025

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