USP14 Antibody

Item no.	OACA03924-100UG
Manufacturer	AVIVA Systems Biology
Amount	100 ug
Category	Oncology Neuroscience Neural Lineage Markers Neuroinflammation Molecular Targets for Neuroscience Antibodies By Cell Type Carcinoma Hematology Leukemia Lymphoma Immunohistochemistry Western Blot ELISA Immunofluorescence Cardiovascular Research Atherosclerosis Primary Antibodies Immunostaining
Type	Antibody Polyclonal
Format	Liquid
Applications	WB, IF, IHC, ELISA
Specific against	Human (Homo sapiens), Mouse (Murine, Mus musculus)
Host	Rabbit
Isotype	IgG
Conjugate/Tag	Unconjugated
Citations	[1]tRNA-guanine transglycosylase cDNA from human placenta.Deshpande K.L., Katze J.R.Submitted (AUG-1995)[2]Cloning of human full-length CDSs in BD Creator(TM) system donor vector.Kalnine N., Chen X., Rolfs A., Halleck A., Hines L., Eisenstein S., Koundi
ECLASS 10.1	32160702
ECLASS 11.0	32160702
UNSPSC	12352203
Alias	deubiquitinating enzyme 14;TGT;tRNA-guanine transglycosylase,60-kD subunit;ubiquitin carboxyl-terminal hydrolase 14;ubiquitin specific peptidase 14 (tRNA-guanine transglycosylase);ubiquitin specific protease 14 (tRNA-guanine transglycosylase);ubiquitin thioesterase 14;ubiquitin thiolesterase 14;ubiquitin-specific processing protease 14;Ubiquitin-specific-processing protease 14.
Available
Manufacturer - Type	Polyclonal Antibody
Manufacturer - Category	Root Catalog/Products/Polyclonal Antibodies, Root Catalog/Products/Primary Antibodies
Gene symbol	USP14
Gene Fullname	ubiquitin specific peptidase 14
Product format	Liquid
Reconstitution and storage	-20°C or -80°C
Description of target	Proteasome-associated deubiquitinase which releases ubiquitin from the proteasome targeted ubiquitinated proteins. Ensures the regeneration of ubiquitin at the proteasome. Is a reversibly associated subunit of the proteasome and a large fraction of proteasome-free protein exists within the cell. Required for the degradation of the chemokine receptor CXCR4 which is critical for CXCL12-induced cell chemotaxis. Serves also as a physiological inhibitor of endoplasmic reticulum-associated degradation (ERAD) under the non-stressed condition by inhibiting the degradation of unfolded endoplasmic reticulum proteins via interaction with ERN1. Indispensable for synaptic development and function at neuromuscular junctions (NMJs). Plays a role in the innate immune defense against viruses by stabilizing the viral DNA sensor CGAS and thus inhibiting its autophagic degradation.
Nucleotide accession_num	NM_001037334
Protein accession_num	NP_001032411
Protein name	Ubiquitin carboxyl-terminal hydrolase 14
Clonality	Polyclonal
Purification	Protein G Purified
Immunogen	Recombinant Human Ubiquitin carboxyl-terminal hydrolase 14 protein (1-494AA)

Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.

All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.

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Amount: 100 ug

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Delivery expected until 12/25/2025

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