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ERBB3 Antibody

ERBB3 Antibody

Item no.	OACA06630-100UL
Manufacturer	AVIVA Systems Biology
Amount	100 ul
Category	Oncology Neuroscience Neural Lineage Markers Metabolism Cholesterol & Lipid Metabolism Molecular Targets for Neuroscience Aging & Neurological Disorders Neural Signaling Neural Adhesion Molecules Antibodies By Cell Type Blastoma Carcinoma Glioma Hematology Lymphoma Myeloma Melanoma Sarcoma Adenocarcinoma Immunohistochemistry ELISA Primary Antibodies Astrocytoma By Organ Bladder Cancer Breast Cancer Immunostaining Glial Cell Markers Neuronal Cell Markers
Type	Antibody Polyclonal
Format	Liquid
Applications	IHC, ELISA
Specific against	Human (Homo sapiens)
Host	Rabbit
Isotype	IgG
Conjugate/Tag	Unconjugated
Citations	[1]Patterns of somatic mutation in human cancer genomes."Greenman C., Stephens P., Smith R., Dalgliesh G.L., Hunter C., Bignell G., Davies H., Teague J., Butler A., Stevens C., Edkins S., O'Meara S., Vastrik I., Schmidt E.E., Avis T., Barthorpe S., Bhamra G., Buck G. Stratton M.R.Nature 446:153-158(2007). [2]Spatial structure and dimer-monomer equilibrium of the ErbB3 transmembrane domain in DPC micelles." Mineev K.S., Khabibullina N.F., Lyukmanova E.N., Dolgikh D.A., Kirpichnikov M.P., Arseniev A.S.Biochim. Biophys. Acta 1808:2081-2088(2011). [3]ErbB3/HER3 intracellular domain is competent to bind ATP and catalyze autophosphorylation." Shi F., Telesco S.E., Liu Y., Radhakrishnan R., Lemmon M.A.Proc. Natl. Acad. Sci. U.S.A. 107:7692-7697(2010)
ECLASS 10.1	32160702
ECLASS 11.0	32160702
UNSPSC	12352203
Alias	c-erbB3;c-erbB-3;ErbB-3;erbB3-S;FERLK;HER3;human epidermal growth factor receptor 3;LCCS2;MDA-BF-1;p180-ErbB3;p45-sErbB3;p85-sErbB3;proto-oncogene-like protein c-ErbB-3;receptor tyrosine-protein kinase erbB-3;tyrosine kinase-type cell surface receptor HER3;v-erb-b2 avian erythroblastic leukemia viral oncogene homolog 3;VSCN1.
Available
Manufacturer - Type	Polyclonal Antibody
Manufacturer - Category	Root Catalog/Products/Polyclonal Antibodies, Root Catalog/Products/Primary Antibodies
Gene symbol	ERBB3
Gene Fullname	erb-b2 receptor tyrosine kinase 3
Product format	Liquid
Reconstitution and storage	-20°C or -80°C
Description of target	Tyrosine-protein kinase that plays an essential role as cell surface receptor for neuregulins. Binds to neuregulin-1 (NRG1) and is activated by it; ligand-binding increases phosphorylation on tyrosine residues and promotes its association with the p85 subunit of phosphatidylinositol 3-kinase (PubMed:20682778). May also be activated by CSPG5 (PubMed:15358134).
Nucleotide accession_num	NM_001005915
Protein accession_num	NP_001005915
Protein name	Receptor tyrosine-protein kinase erbB-3
Clonality	Polyclonal
Purification	Affinity Purified
Immunogen	Recombinant Human Receptor tyrosine-protein kinase erbB-3 protein (20-285AA)

Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.

All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.

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Amount: 100 ul

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Delivery expected until 11/27/2025

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