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CD274 Antibody

CD274 Antibody

Item no.	OACA06799
Manufacturer	AVIVA Systems Biology
Amount	50 ul
Category	Oncology Neuroscience Neuroinflammation Antibodies By Cell Type Carcinoma Hematology Lymphoma Cell Biology Cell Culture Cytokines Myelofibrosis Immunohistochemistry Western Blot ELISA Immunofluorescence Primary Antibodies Immunostaining
Type	Antibody Polyclonal
Format	Liquid
Applications	IHC, ELISA
Specific against	Human (Homo sapiens)
Host	Rabbit
Isotype	IgG
Conjugate/Tag	Unconjugated
Citations	[1]The PD-1/PD-L1 complex resembles the antigen-binding Fv domains of antibodies and T cell receptors." Lin D.Y., Tanaka Y., Iwasaki M., Gittis A.G., Su H.P., Mikami B., Okazaki T., Honjo T., Minato N., Garboczi D.N. Proc. Natl. Acad. Sci. U.S.A. 105:3011-3016(2008). [2]Glycoproteomics analysis of human liver tissue by combination of multiple enzyme digestion and hydrazide chemistry."Chen R., Jiang X., Sun D., Han G., Wang F., Ye M., Wang L., Zou H.J. Proteome Res. 8:651-661(2009). [3]The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."The MGC Project TeamGenome Res. 14:2121-2127(2004).
ECLASS 10.1	32160702
ECLASS 11.0	32160702
UNSPSC	12352203
Alias	B7 homolog 1;B7-H;B7H1;CD274 antigen;hPD-L1;PDCD1 ligand 1;PDCD1L1;PDCD1LG1;PDL1;PD-L1;programmed cell death 1 ligand 1.
Shipping Condition	Cool pack
Available
Manufacturer - Type	Polyclonal Antibody
Manufacturer - Category	Root Catalog/Products/Polyclonal Antibodies, Root Catalog/Products/Primary Antibodies
Shipping Temperature	Wet Ice
Gene symbol	CD274
Gene Fullname	CD274 molecule
Product format	Liquid
Reconstitution and storage	-20°C or -80°C
Description of target	Plays a critical role in induction and maintenance of immune tolerance to self. As a ligand for the inhibitory receptor PDCD1/CD279, modulates the activation threshold of T-cells and limits T-cell effector response (PubMed:11015443). The PDCD1/CD279-mediated inhibitory pathway is exploited by tumors to attenuate anti-tumor immunity and facilitate tumor survival (PubMed:28813417, PubMed:28813410). Through a yet unknown activating receptor, may costimulate T-cell subsets that predominantly produce interleukin-10 (IL10) (PubMed:10581077).
Nucleotide accession_num	NM_001267706
Protein accession_num	NP_001254635
Protein name	Programmed cell death 1 ligand 1
Clonality	Polyclonal
Purification	Affinity Purified
Immunogen	Recombinant Human Programmed cell death 1 ligand 1 protein (19-238AA)
Formulation	PBS with, 50% glycerol, pH7.3.

Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.

All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.

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Amount: 50 ul

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Delivery expected until 10/30/2025

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