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EGLN1 Antibody

EGLN1 Antibody

Item no.	OACA06860
Manufacturer	AVIVA Systems Biology
Amount	50 ul
Category	Oncology Antibodies By Cell Type Carcinoma Immunohistochemistry Western Blot ELISA Primary Antibodies Immunostaining
Type	Antibody Polyclonal
Format	Liquid
Applications	WB, IHC, ELISA
Specific against	Human (Homo sapiens), Rat (Rattus norvegicus)
Host	Rabbit
Isotype	IgG
Conjugate/Tag	Unconjugated
Citations	[1]"A genetic mechanism for Tibetan high-altitude adaptation." Lorenzo F.R., Huff C., Myllymaeki M., Olenchock B., Swierczek S., Tashi T., Gordeuk V., Wuren T., Ri-Li G., McClain D.A., Khan T.M., Koul P.A., Guchhait P., Salama M.E., Xing J., Semenza G.L., Liberzon E., Wilson A. Prchal J.T.Nat. Genet. 46:951-956(2014). [2]"Defective Tibetan PHD2 binding to p23 links high altitude adaption to altered oxygen sensing."Song D., Li L.S., Arsenault P.R., Tan Q., Bigham A.W., Heaton-Johnson K.J., Master S.R., Lee F.S.J. Biol. Chem. 289:14656-14665(2014). [3]"A novel erythrocytosis-associated PHD2 mutation suggests the location of a HIF binding groove."Percy M.J., Furlow P.W., Beer P.A., Lappin T.R.J., McMullin M.F., Lee F.S.Blood 110:2193-2196(2007).
ECLASS 10.1	32160702
ECLASS 11.0	32160702
UNSPSC	12352203
Alias	C1orf12;ECYT3;egl nine homolog 1;egl nine-like protein 1;HALAH;HIFPH2;HIF-PH2;HIF-prolyl hydroxylase 2;HPH2;HPH-2;hypoxia-inducible factor prolyl hydroxylase 2;PHD2;prolyl hydroxylase domain-containing protein 2;SM20;SM-20;zinc finger MYND domain-containing protein 6;ZMYND6.
Shipping Condition	Cool pack
Available
Manufacturer - Type	Polyclonal Antibody
Manufacturer - Category	Root Catalog/Products/Polyclonal Antibodies, Root Catalog/Products/Primary Antibodies
Shipping Temperature	Wet Ice
Gene symbol	EGLN1
Gene Fullname	egl-9 family hypoxia inducible factor 1
Product format	Liquid
Reconstitution and storage	-20°C or -80°C
Description of target	Cellular oxygen sensor that catalyzes, under normoxic conditions, the post-translational formation of 4-hydroxyproline in hypoxia-inducible factor (HIF) alpha proteins. Hydroxylates a specific proline found in each of the oxygen-dependent degradation (ODD) domains (N-terminal, NODD, and C-terminal, CODD) of HIF1A. Also hydroxylates HIF2A. Has a preference for the CODD site for both HIF1A and HIF1B. Hydroxylated HIFs are then targeted for proteasomal degradation via the von Hippel-Lindau ubiquitination complex. Under hypoxic conditions, the hydroxylation reaction is attenuated allowing HIFs to escape degradation resulting in their translocation to the nucleus, heterodimerization with HIF1B, and increased expression of hypoxy-inducible genes. EGLN1 is the most important isozyme under normoxia and, through regulating the stability of HIF1, involved in various hypoxia-influenced processes such as angiogenesis in retinal and cardiac functionality. Target proteins are preferentially recognized via a LXXLAP motif.
Nucleotide accession_num	NM_022051
Protein accession_num	NP_071334
Protein name	Egl nine homolog 1
Clonality	Polyclonal
Purification	Affinity Purified
Immunogen	Recombinant Human Egl nine homolog 1 protein (301-426AA)
Formulation	PBS with, 50% glycerol, pH7.3.

Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.

All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.

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Amount: 50 ul

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Delivery expected until 12/25/2025

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