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PIAS3 Antibody

PIAS3 Antibody

Item no.	OACA06987-100UL
Manufacturer	AVIVA Systems Biology
Amount	100 ul
Category	Oncology Neuroscience Neural Lineage Markers Neural Transcription Factors Antibodies By Cell Type Blastoma Carcinoma Glioma Hematology Leukemia Lymphoma Myeloma Melanoma Adenocarcinoma Immunohistochemistry Western Blot ELISA Primary Antibodies Immunostaining
Type	Antibody Polyclonal
Format	Liquid
Applications	IHC, ELISA
Specific against	Human (Homo sapiens)
Host	Rabbit
Isotype	IgG
Conjugate/Tag	Unconjugated
Citations	[1]"SUMOylation and SUMO-interacting motif (SIM) of metastasis tumor antigen 1 (MTA1) synergistically regulate its transcriptional repressor function."Cong L., Pakala S.B., Ohshiro K., Li D.Q., Kumar R.J. Biol. Chem. 286:43793-43808(2011). [2]"Repression of the transactivating capacity of the oncoprotein PLAG1 by SUMOylation." Van Dyck F., Delvaux E.L.D., Van de Ven W.J.M., Chavez M.V.J. Biol. Chem. 279:36121-36131(2004). [3]"ATBF1 enhances the suppression of STAT3 signaling by interaction with PIAS3." Nojiri S., Joh T., Miura Y., Sakata N., Nomura T., Nakao H., Sobue S., Ohara H., Asai K., Ito M.Biochem. Biophys. Res. Commun. 314:97-103(2004).
ECLASS 10.1	32160702
ECLASS 11.0	32160702
UNSPSC	12352203
Alias	E3 SUMO-protein ligase PIAS3;E3 SUMO-protein transferase PIAS3;protein inhibitor of activated STAT protein 3;zinc finger,MIZ-type containing 5;ZMIZ5.
Available
Manufacturer - Type	Polyclonal Antibody
Manufacturer - Category	Root Catalog/Products/Polyclonal Antibodies, Root Catalog/Products/Primary Antibodies
Gene symbol	PIAS3
Gene Fullname	protein inhibitor of activated STAT 3
Product format	Liquid
Reconstitution and storage	-20°C or -80°C
Description of target	Functions as an E3-type small ubiquitin-like modifier (SUMO) ligase, stabilizing the interaction between UBE2I and the substrate, and as a SUMO-tethering factor. Plays a crucial role as a transcriptional coregulation in various cellular pathways, including the STAT pathway and the steroid hormone signaling pathway. Involved in regulating STAT3 signaling via inhibiting STAT3 DNA-binding and suppressing cell growth. Enhances the sumoylation of MTA1 and may participate in its paralog-selective sumoylation (PubMed:21965678, PubMed:9388184). Sumoylates CCAR2 which promotes its interaction with SIRT1 (PubMed:25406032). Diminishes the sumoylation of ZFHX3 by preventing the colocalization of ZFHX3 with SUMO1 in the nucleus (PubMed:24651376).
Nucleotide accession_num	NM_006099
Protein accession_num	NP_006090
Protein name	E3 SUMO-protein ligase PIAS3
Clonality	Polyclonal
Purification	Affinity Purified
Immunogen	Recombinant Human E3 SUMO-protein ligase PIAS3 protein (399-628AA)

Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.

All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.

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Amount: 100 ul

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Delivery expected until 12/11/2025

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