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ATG14 Antibody

ATG14 Antibody

Item no.	OACA07103
Manufacturer	AVIVA Systems Biology
Amount	50 ul
Category	Oncology Neuroscience Neural Signaling Antibodies By Cell Type Cell Biology Cell Status Immunohistochemistry ELISA Autophagy Cardiovascular Research Myocardial Infarction Primary Antibodies Immunostaining
Type	Antibody Polyclonal
Format	Liquid
Applications	IHC, ELISA
Specific against	Human (Homo sapiens)
Host	Rabbit
Isotype	IgG
Conjugate/Tag	Unconjugated
Citations	[1]"Beclin 2 functions in autophagy, degradation of G protein-coupled receptors, and metabolism."He C., Wei Y., Sun K., Li B., Dong X., Zou Z., Liu Y., Kinch L.N., Khan S., Sinha S., Xavier R.J., Grishin N.V., Xiao G., Eskelinen E.L., Scherer P.E., Whistler J.L., Levine B.Cell 154:1085-1099(2013). [2]"Imperfect interface of Beclin1 coiled-coil domain regulates homodimer and heterodimer formation with Atg14L and UVRAG."Li X., He L., Che K.H., Funderburk S.F., Pan L., Pan N., Zhang M., Yue Z., Zhao Y.Nat. Commun. 3:662-662(2012). [3]"Autophagy requires endoplasmic reticulum targeting of the PI3-kinase complex via Atg14L."Matsunaga K., Morita E., Saitoh T., Akira S., Ktistakis N.T., Izumi T., Noda T., Yoshimori T.J. Cell Biol. 190:511-521(2010).
ECLASS 10.1	32160702
ECLASS 11.0	32160702
UNSPSC	12352203
Alias	ATG14 autophagy related 14 homolog;ATG14L;autophagy-related protein 14-like protein;BARKOR;beclin 1-associated autophagy-related key regulator;Beclin 1-Interacting protein;KIAA0831.
Shipping Condition	Cool pack
Available
Manufacturer - Type	Polyclonal Antibody
Manufacturer - Category	Root Catalog/Products/Polyclonal Antibodies, Root Catalog/Products/Primary Antibodies
Shipping Temperature	Wet Ice
Gene symbol	ATG14
Gene Fullname	autophagy related 14
Product format	Liquid
Reconstitution and storage	-20°C or -80°C
Description of target	Required for both basal and inducible autophagy. Determines the localization of the autophagy-specific PI3-kinase complex PI3KC3-C1 (PubMed:18843052, PubMed:19050071). Plays a role in autophagosome formation and MAP1LC3/LC3 conjugation to phosphatidylethanolamine (PubMed:19270696, PubMed:20713597). Promotes BECN1 translocation from the trans-Golgi network to autophagosomes (PubMed:20713597). Enhances PIK3C3 activity in a BECN1-dependent manner. Essential for the autophagy-dependent phosphorylation of BECN1 (PubMed:23878393). Stimulates the phosphorylation of BECN1, but suppresses the phosphorylation PIK3C3 by AMPK (PubMed:23878393). Binds to STX17-SNAP29 binary t-SNARE complex on autophagosomes and primes it for VAMP8 interaction to promote autophagosome-endolysosome fusion (PubMed:25686604). Modulates the hepatic lipid metabolism (By similarity).
Nucleotide accession_num	NM_014924
Protein accession_num	NP_055739
Protein name	Beclin 1-associated autophagy-related key regulator
Clonality	Polyclonal
Purification	Affinity Purified
Immunogen	Recombinant Human Beclin 1-associated autophagy-related key regulator protein (1-310AA)
Formulation	PBS with, 50% glycerol, pH7.3.

Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.

All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.

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