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MECP2 Antibody

MECP2 Antibody

Item no.	OACA07153-100UL
Manufacturer	AVIVA Systems Biology
Amount	100 ul
Category	Neuroscience Neural Lineage Markers Molecular Targets for Neuroscience Neural Epigenetics Antibodies Immunohistochemistry ELISA Primary Antibodies Immunostaining Glial Cell Markers
Type	Antibody Polyclonal
Format	Liquid
Applications	IHC, ELISA
Specific against	Human (Homo sapiens)
Host	Rabbit
Isotype	IgG
Conjugate/Tag	Unconjugated
Citations	[1]"Interaction between chromatin proteins MECP2 and ATRX is disrupted by mutations that cause inherited mental retardation."Nan X., Hou J., Maclean A., Nasir J., Lafuente M.J., Shu X., Kriaucionis S., Bird A.Proc. Natl. Acad. Sci. U.S.A. 104:2709-2714(2007). [2]"A novel familial MECP2 mutation in a young boy: clinical and molecular findings."Ventura P., Galluzzi R., Bacca S.M., Giorda R., Massagli A. Neurology 67:867-868(2006). [3]"Duplication of the MECP2 region is a frequent cause of severe mental retardation and progressive neurological symptoms in males."Van Esch H., Bauters M., Ignatius J., Jansen M., Raynaud M., Hollanders K., Lugtenberg D., Bienvenu T., Jensen L.R., Gecz J., Moraine C., Marynen P., Fryns J.-P., Froyen G.Am. J. Hum. Genet. 77:442-453(2005).
ECLASS 10.1	32160702
ECLASS 11.0	32160702
UNSPSC	12352203
Alias	AUTSX3;meCp-2 protein;methyl-CpG-binding protein 2;MRX16;MRX79;MRXS13;MRXSL;PPMX;RS;RTS;RTT.
Available
Manufacturer - Type	Polyclonal Antibody
Manufacturer - Category	Root Catalog/Products/Polyclonal Antibodies, Root Catalog/Products/Primary Antibodies
Gene symbol	MECP2
Gene Fullname	methyl-CpG binding protein 2
Product format	Liquid
Reconstitution and storage	-20°C or -80°C
Description of target	Chromosomal protein that binds to methylated DNA. It can bind specifically to a single methyl-CpG pair. It is not influenced by sequences flanking the methyl-CpGs. Mediates transcriptional repression through interaction with histone deacetylase and the corepressor SIN3A. Binds both 5-methylcytosine (5mC) and 5-hydroxymethylcytosine (5hmC)-containing DNA, with a preference for 5-methylcytosine (5mC).
Nucleotide accession_num	NM_001110792
Protein accession_num	NP_001104262
Protein name	Methyl-CpG-binding protein 2
Clonality	Polyclonal
Purification	Affinity Purified
Immunogen	Recombinant Human Methyl-CpG-binding protein 2 protein (1-280AA)

Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.

All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.

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Amount: 100 ul

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Delivery expected until 11/27/2025

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