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AKAP8L Antibody

AKAP8L Antibody

Item no.	OACA07466
Manufacturer	AVIVA Systems Biology
Amount	50 ul
Category	Oncology Neuroscience Aging & Neurological Disorders Neural Epigenetics Antibodies By Cell Type Carcinoma Melanoma Immunohistochemistry ELISA Primary Antibodies Immunostaining
Type	Antibody Polyclonal
Format	Liquid
Applications	IHC, ELISA
Specific against	Human (Homo sapiens)
Host	Rabbit
Isotype	IgG
Conjugate/Tag	Unconjugated
Citations	[1]"Identification, cloning and characterization of a novel nuclear protein, HA95, homologous to A-kinase anchoring protein 95."Orstavik S., Eide T., Collas P., Han I.O., Tasken K., Kieff E., Jahnsen T., Skalhegg B.S.Biol. Cell 92:27-37(2000). [2]"A novel shuttle protein binds to RNA helicase A and activates the retroviral constitutive transport element."Westberg C., Yang J.-P., Tang H., Reddy T.R., Wong-Staal F.J. Biol. Chem. 275:21396-21401(2000). [3]"Complete sequencing and characterization of 21,243 full-length human cDNAs."Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. Sugano S. Nat. Genet. 36:40-45(2004).
ECLASS 10.1	32160702
ECLASS 11.0	32160702
UNSPSC	12352203
Alias	A kinase (PRKA) anchor protein 8-like;AKAP8-like protein;A-kinase anchor protein 8-like;HA95;HAP95;Helicase A-binding protein 95;helicase A-binding protein 95 kDa;homologous to AKAP95 protein;NAKAP;NAKAP95;neighbor of AKAP95;neighbor of A-kinase anchoring protein 95;Neighbor of A-kinase-anchoring protein 95;testis tissue sperm-binding protein Li 90mP.
Shipping Condition	Cool pack
Available
Manufacturer - Type	Polyclonal Antibody
Manufacturer - Category	Root Catalog/Products/Polyclonal Antibodies, Root Catalog/Products/Primary Antibodies
Shipping Temperature	Wet Ice
Gene symbol	AKAP8L
Gene Fullname	A-kinase anchoring protein 8 like
Product format	Liquid
Reconstitution and storage	-20°C or -80°C
Description of target	Could play a role in constitutive transport element (CTE)-mediated gene expression by association with DHX9. Increases CTE-dependent nuclear unspliced mRNA export (PubMed:10748171, PubMed:11402034). Proposed to target PRKACA to the nucleus but does not seem to be implicated in the binding of regulatory subunit II of PKA (PubMed:10761695, PubMed:11884601). May be involved in nuclear envelope breakdown and chromatin condensation. May be involved in anchoring nuclear membranes to chromatin in interphase and in releasing membranes from chromating at mitosis (PubMed:11034899). May regulate the initiation phase of DNA replication when associated with TMPO isoform Beta (PubMed:12538639). Required for cell cycle G2/M transition and histone deacetylation during mitosis. In mitotic cells recruits HDAC3 to the vicinity of chromatin leading to deacetylation and subsequent phosphorylation at 'Ser-10' of histone H3; in this function seems to act redundantly with AKAP8 (PubMed:16980585). May be involved in regulation of pre-mRNA splicing (PubMed:17594903).
Nucleotide accession_num	NM_001291478
Protein accession_num	NP_001278407
Protein name	A-kinase anchor protein 8-like
Clonality	Polyclonal
Purification	Affinity Purified
Immunogen	Recombinant Human A-kinase anchor protein 8-like protein (1-240AA)
Formulation	PBS with, 50% glycerol, pH7.3.

Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.

All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.

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Amount: 50 ul

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Delivery expected until 11/13/2025

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