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GAN Antibody

GAN Antibody

Item no.	OACA07479
Manufacturer	AVIVA Systems Biology
Amount	50 ul
Category	Neuroscience Neural Lineage Markers Antibodies Immunohistochemistry ELISA Primary Antibodies Immunostaining Glial Cell Markers
Type	Antibody Polyclonal
Format	Liquid
Applications	IHC, ELISA
Specific against	Human (Homo sapiens)
Host	Rabbit
Isotype	IgG
Conjugate/Tag	Unconjugated
Citations	[1]"Targeting of protein ubiquitination by BTB-Cullin 3-Roc1 ubiquitin ligases." Furukawa M., He Y.J., Borchers C., Xiong Y.Nat. Cell Biol. 5:1001-1007(2003). [2]"Gigaxonin interacts with tubulin folding cofactor B and controls its degradation through the ubiquitin-proteasome pathway."Wang W., Ding J., Allen E., Zhu P., Zhang L., Vogel H., Yang Y.Curr. Biol. 15:2050-2055(2005). [3]"Ubiquitination of Keap1, a BTB-Kelch substrate adaptor protein for Cul3, targets Keap1 for degradation by a proteasome-independent pathway."Zhang D.D., Lo S.C., Sun Z., Habib G.M., Lieberman M.W., Hannink M.J. Biol. Chem. 280:30091-30099(2005).
ECLASS 10.1	32160702
ECLASS 11.0	32160702
UNSPSC	12352203
Alias	epididymis secretory sperm binding protein;GAN1;GIG;gigaxonin;kelch-like family member 16;kelch-like protein 16;KLHL16.
Shipping Condition	Cool pack
Available
Manufacturer - Type	Polyclonal Antibody
Manufacturer - Category	Root Catalog/Products/Polyclonal Antibodies, Root Catalog/Products/Primary Antibodies
Shipping Temperature	Wet Ice
Gene symbol	GAN
Gene Fullname	gigaxonin
Product format	Liquid
Reconstitution and storage	-20°C or -80°C
Description of target	Probable cytoskeletal component that directly or indirectly plays an important role in neurofilament architecture. May act as a substrate-specific adapter of an E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Controls degradation of TBCB. Controls degradation of MAP1B and MAP1S, and is critical for neuronal maintenance and survival.
Nucleotide accession_num	NM_022041
Protein accession_num	NP_071324
Protein name	Gigaxonin
Clonality	Polyclonal
Purification	Affinity Purified
Immunogen	Recombinant Human Gigaxonin protein (1-240AA)
Formulation	PBS with, 50% glycerol, pH7.3.

Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.

All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.

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Amount: 50 ul

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Delivery expected until 11/13/2025

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