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PARL Antibody

PARL Antibody

Item no.	OACA07509
Manufacturer	AVIVA Systems Biology
Amount	50 ul
Category	Neuroscience Molecular Targets for Neuroscience Antibodies Immunohistochemistry ELISA Primary Antibodies Immunostaining
Type	Antibody Polyclonal
Format	Liquid
Applications	IHC, ELISA
Specific against	Human (Homo sapiens)
Host	Rabbit
Isotype	IgG
Conjugate/Tag	Unconjugated
Citations	[1]"Self-regulated cleavage of the mitochondrial intramembrane-cleaving protease PARL yields Pbeta, a nuclear-targeted peptide."Sik A., Passer B.J., Koonin E.V., Pellegrini L.J. Biol. Chem. 279:15323-15329(2004). [2]"Phosphorylation and cleavage of presenilin-associated rhomboid-like protein (PARL) promotes changes in mitochondrial morphology."Jeyaraju D.V., Xu L., Letellier M.-C., Bandaru S., Zunino R., Berg E.A., McBride H.M., Pellegrini L.Proc. Natl. Acad. Sci. U.S.A. 103:18562-18567(2006). [3]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."The MGC Project TeamGenome Res. 14:2121-2127(2004).
ECLASS 10.1	32160702
ECLASS 11.0	32160702
UNSPSC	12352203
Alias	Mitochondrial intramembrane cleaving protease PARL;mitochondrial intramembrane-cleaving protease PARL;presenilins-associated rhomboid-like protein,mitochondrial;PRO2207;PSARL;PSARL1;PSENIP2;RHBDS1;rhomboid 7 homolog 1.
Shipping Condition	Cool pack
Available
Manufacturer - Type	Polyclonal Antibody
Manufacturer - Category	Root Catalog/Products/Polyclonal Antibodies, Root Catalog/Products/Primary Antibodies
Shipping Temperature	Wet Ice
Gene symbol	PARL
Gene Fullname	presenilin associated rhomboid like
Product format	Liquid
Reconstitution and storage	-20°C or -80°C
Description of target	Required for the control of apoptosis during postnatal growth. Essential for proteolytic processing of an antiapoptotic form of OPA1 which prevents the release of mitochondrial cytochrome c in response to intrinsic apoptoptic signals (By similarity). Promotes changes in mitochondria morphology regulated by phosphorylation of P-beta domain.
Nucleotide accession_num	NM_001037639
Protein accession_num	NP_001032728
Protein name	Presenilins-associated rhomboid-like protein, mitochondrial
Clonality	Polyclonal
Purification	Affinity Purified
Immunogen	Recombinant Human Presenilins-associated rhomboid-like protein, mitochondrial protein (1-170AA)
Formulation	PBS with, 50% glycerol, pH7.3.

Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.

All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.

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Amount: 50 ul

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Delivery expected until 11/13/2025

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