Comparison

SYVN1 Antibody

Item no. OACA09917
Manufacturer AVIVA Systems Biology
Amount 50 ug
Category
Type Antibody Polyclonal
Format Liquid
Applications IF, IHC, ELISA
Specific against Human (Homo sapiens)
Host Rabbit
Isotype IgG
Conjugate/Tag Unconjugated
Purity >95%
ECLASS 10.1 32160702
ECLASS 11.0 32160702
UNSPSC 12352203
Alias DER3;E3 ubiquitin-protein ligase synoviolin;HMG-coA reductase degradation 1 homolog;HRD1;RING-type E3 ubiquitin transferase synoviolin;Synovial apoptosis inhibitor 1;synovial apoptosis inhibitor 1,synoviolin.
Shipping Condition Cool pack
Available
Manufacturer - Type
Polyclonal Antibody
Manufacturer - Category
Root Catalog/Products/Polyclonal Antibodies, Root Catalog/Products/Primary Antibodies
Shipping Temperature
Wet Ice
Gene symbol
SYVN1
Gene Fullname
synoviolin 1
Product format
Liquid
Reconstitution and storage
-20°C or -80°C
Description of target
Acts as an E3 ubiquitin-protein ligase which accepts ubiquitin specifically from endoplasmic reticulum-associated UBC7 E2 ligase and transfers it to substrates, promoting their degradation (PubMed:12459480, PubMed:12646171, PubMed:12975321, PubMed:14593114, PubMed:16289116, PubMed:16847254, PubMed:17059562, PubMed:17141218, PubMed:17170702, PubMed:22607976, PubMed:26471130). Component of the endoplasmic reticulum quality control (ERQC) system also called ER-associated degradation (ERAD) involved in ubiquitin-dependent degradation of misfolded endoplasmic reticulum proteins (PubMed:12459480, PubMed:12646171, PubMed:12975321, PubMed:14593114, PubMed:16289116, PubMed:16847254, PubMed:17059562, PubMed:17141218, PubMed:17170702, PubMed:22607976, PubMed:26471130). Also promotes the degradation of normal but naturally short-lived proteins such as SGK. Protects cells from ER stress-induced apoptosis. Protects neurons from apoptosis induced by polyglutamine-expanded huntingtin (HTT) or unfolded GPR37 by promoting their degradation (PubMed:17141218). Sequesters p53/TP53 in the cytoplasm and promotes its degradation, thereby negatively regulating its biological function in transcription, cell cycle regulation and apoptosis (PubMed:17170702). Mediates the ubiquitination and subsequent degradation of cytoplasmic NFE2L1 (By similarity).
Nucleotide accession_num
NM_032431
Protein accession_num
NP_115807
Protein name
E3 ubiquitin-protein ligase synoviolin
Clonality
Polyclonal
Purification
Protein G Purified
Immunogen
Recombinant Human E3 ubiquitin-protein ligase synoviolin protein (338-487AA)
Formulation
50% Glycerol, 0.01M PBS, PH 7.4

Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.

All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.

Amount: 50 ug
Available: In stock
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