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NOD2 Antibody

NOD2 Antibody

Item no.	OACA10693
Manufacturer	AVIVA Systems Biology
Amount	50 ug
Category	Oncology Neuroscience Neuroinflammation Metabolism Cholesterol & Lipid Metabolism Targets for Rodent Neurosciences Neural Signaling Antibodies By Cell Type Carcinoma Hematology Leukemia Lymphoma Myeloma Cell Biology Cell Movement Cell Adhesion Cell Culture Cytokines Cell Status Apoptosis Immunohistochemistry Western Blot ELISA Immunofluorescence Immunocytochemistry Autophagy Primary Antibodies By Organ Breast Cancer Immunostaining
Type	Antibody Polyclonal
Format	Liquid
Applications	IF, IHC, ELISA
Specific against	Human (Homo sapiens)
Host	Rabbit
Isotype	IgG
Conjugate/Tag	Unconjugated
Purity	>95%
ECLASS 10.1	32160702
ECLASS 11.0	32160702
UNSPSC	12352203
Alias	ACUG;BLAU;BLAUS;CARD15;caspase recruitment domain family,member 15;caspase recruitment domain protein 15;caspase recruitment domain-containing protein 15;CD;CLR16.3;IBD1;inflammatory bowel disease protein 1;NLR family,CARD domain containing 2;NLRC2;NOD2B;NOD-like receptor C2;nucleotide-binding oligomerization domain 2;nucleotide-binding oligomerization domain,leucine rich repeat and CARD domain containing 2;nucleotide-binding oligomerization domain-containing protein 2;PSORAS1;YAOS.
Shipping Condition	Cool pack
Available
Manufacturer - Type	Polyclonal Antibody
Manufacturer - Category	Root Catalog/Products/Polyclonal Antibodies, Root Catalog/Products/Primary Antibodies
Shipping Temperature	Wet Ice
Gene symbol	NOD2
Gene Fullname	nucleotide binding oligomerization domain containing 2
Product format	Liquid
Reconstitution and storage	-20°C or -80°C
Description of target	Involved in gastrointestinal immunity. Upon stimulation by muramyl dipeptide (MDP), a fragment of bacterial peptidoglycan, binds the proximal adapter receptor-interacting RIPK2, which recruits ubiquitin ligases as XIAP, BIRC2, BIRC3, INAVA and the LUBAC complex, triggering activation of MAP kinases and activation of NF-kappa-B signaling. This in turn leads to the transcriptional activation of hundreds of genes involved in immune response. Required for MDP-induced NLRP1-dependent CASP1 activation and IL1B release in macrophages (PubMed:18511561). Component of an autophagy-mediated antibacterial pathway together with ATG16L1 (PubMed:20637199). Plays also a role in sensing single-stranded RNA (ssRNA) from viruses. Interacts with mitochondrial antiviral signaling/MAVS, leading to activation of interferon regulatory factor-3/IRF3 and expression of type I interferon (PubMed:19701189).
Nucleotide accession_num	NM_001293557
Protein accession_num	NP_001280486
Protein name	Nucleotide-binding oligomerization domain-containing protein 2
Clonality	Polyclonal
Purification	Protein G Purified
Immunogen	Recombinant Human Nucleotide-binding oligomerization domain-containing protein 2 protein (460-733AA)
Formulation	50% Glycerol, 0.01M PBS, pH 7.4

Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.

All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.

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Amount: 50 ug

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Delivery expected until 10/30/2025

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