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SIGLEC7 Antibody

SIGLEC7 Antibody

Item no.	OACD00312
Manufacturer	AVIVA Systems Biology
Amount	100 ul
Category	Oncology Neuroscience Neuroinflammation Antibodies By Cell Type Hematology Leukemia Flow Cytometry Immunohistochemistry Immunoprecipitation Western Blot Immunocytochemistry Primary Antibodies By Organ Heart & Blood Cancer Immunochemistry
Type	Antibody Monoclonal
Format	Liquid
Applications	WB, IP, IHC, ICC
Specific against	Human (Homo sapiens), Pig (Porcine, Sus scrofa domesticus)
Host	Mouse
Isotype	IgG
ECLASS 10.1	42030590
ECLASS 11.0	42030590
UNSPSC	12352203
Alias	Adhesion inhibitory receptor molecule 1;adhesion inhibitory receptor molecule 1,siglec-7;AIRM1;AIRM-1;CD328;CDw328;D-siglec;p75;p75/AIRM1;QA79;QA79 membrane protein;sialic acid binding immunoglobulin-like lectin 7;sialic acid-binding Ig-like lectin 7;SIGLEC19P;SIGLEC-7;SIGLECP2.
Shipping Condition	Cool pack
Available
Manufacturer - Type	Monoclonal Antibody
Manufacturer - Category	Root Catalog/Products/Monoclonal Antibodies, Root Catalog/Products/Primary Antibodies
Shipping Temperature	Wet Ice
Manufacturer - Application Additional Information	Western blotting: 1:100-400 Immunocytochemistry in formalin fixed cells: 1:50-500 Immunohistochemistry in formalin fixed frozen section: 1:50-500 Immunohistochemistry in paraffin section: 1:10-100 Enzyme-linked Immunosorbent Assay: 1:100-1:5000 Optimal working dilutions must be determined by end user.
Gene symbol	SIGLEC7
Gene Fullname	sialic acid binding Ig like lectin 7
Product format	Liquid. 0.01M PBS, pH7.4, containing 0.05% Proclin-300, 50% glycerol.
Reconstitution and storage	2°C to 8°C\|-20°C
Description of target	Putative adhesion molecule that mediates sialic-acid dependent binding to cells. Preferentially binds to alpha-2, 3- and alpha-2, 6-linked sialic acid. Also binds disialogangliosides (disialogalactosyl globoside, disialyl lactotetraosylceramide and disialyl GalNAc lactotetraoslylceramide). The sialic acid recognition site may be masked by cis interactions with sialic acids on the same cell surface. In the immune response, may act as an inhibitory receptor upon ligand induced tyrosine phosphorylation by recruiting cytoplasmic phosphatase(s) via their SH2 domain(s) that block signal transduction through dephosphorylation of signaling molecules. Mediates inhibition of natural killer cells cytotoxicity. May play a role in hemopoiesis. Inhibits differentiation of CD34+ cell precursors towards myelomonocytic cell lineage and proliferation of leukemic myeloid cells (in vitro).
Nucleotide accession_num	NM_001277201.1
Protein accession_num	NP_001264130.1
Protein name	Sialic acid-binding Ig-like lectin 7
Clonality	Monoclonal
Purification	Protein A/G Purified
Formulation	PBS, pH7.4, containing 0.02% NaN3, 50% glycerol.
Concentration	1 mg/ml

Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.

All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.

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Amount: 100 ul

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Delivery expected until 11/13/2025

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