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TOPBP1 Antibody

TOPBP1 Antibody

Item no.	OACD00492
Manufacturer	AVIVA Systems Biology
Amount	100 ul
Category	Oncology Antibodies By Cell Type Blastoma Carcinoma Hematology Leukemia Lymphoma Myeloma Melanoma Sarcoma Immunohistochemistry Immunoprecipitation Western Blot Immunocytochemistry Primary Antibodies Immunochemistry
Type	Antibody Polyclonal
Format	Liquid
Applications	WB, IP, IHC, ICC
Specific against	Human (Homo sapiens), Mouse (Murine, Mus musculus), Rat (Rattus norvegicus)
Host	Rabbit
Isotype	IgG
ECLASS 10.1	32160702
ECLASS 11.0	32160702
UNSPSC	12352203
Alias	1110031N14Rik;2810429C13Rik;AI256758;D430026L04Rik;DNA topoisomerase 2-binding protein 1;DNA topoisomerase II-beta-binding protein 1;DNA topoisomerase II-binding protein 1;mKIAA0259;topoisomerase (DNA) II beta binding protein.
Shipping Condition	Cool pack
Available
Manufacturer - Type	Polyclonal Antibody
Manufacturer - Category	Root Catalog/Products/Polyclonal Antibodies, Root Catalog/Products/Primary Antibodies
Shipping Temperature	Wet Ice
Molecular Weight	169 kDa
Application Data	Western blotting: 1:50-400 Immunocytochemistry in formalin fixed cells: 1:50-500 Immunohistochemistry in formalin fixed frozen section: 1:50-500 Immunohistochemistry in paraffin section: 1:10-100 Enzyme-linked Immunosorbent Assay: 1:100-1:5, 000 Optimal working dilutions must be determined by end user.
Gene symbol	Topbp1
Gene Fullname	topoisomerase (DNA) II binding protein 1
Product format	Liquid. 0.01M PBS, pH7.4, containing 0.05% Proclin-300, 50% glycerol.
Reconstitution and storage	2°C to 8°C\|-20°C
Description of target	Required for DNA replication (By similarity). Plays a role in the rescue of stalled replication forks and checkpoint control (PubMed:14718568). Binds double-stranded DNA breaks and nicks as well as single-stranded DNA (By similarity). Recruits the SWI/SNF chromatin remodeling complex to E2F1-responsive promoters. Down-regulates E2F1 activity and inhibits E2F1-dependent apoptosis during G1/S transition and after DNA damage (By similarity). Induces a large increase in the kinase activity of ATR (By similarity).
Nucleotide accession_num	NM_176979
Protein accession_num	NP_795953.2
Protein name	DNA topoisomerase 2-binding protein 1
Clonality	Polyclonal
Purification	Affinity Purified; Protein A Purified
Immunogen	Range: Met1 - Pro246
Manufacturer - Specificity	The antibody is a rabbit polyclonal antibody raised against TOPBP1. It has been selected for its ability to recognize TOPBP1 in immunohistochemical staining and western blotting.
Formulation	PBS, pH7.4, containing 0.02% NaN3, 50% glycerol
Concentration	0.5 mg/ml

Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.

All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.

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Amount: 100 ul

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Delivery expected until 12/25/2025

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