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TAP2 Antibody

TAP2 Antibody

Item no.	OACD00688
Manufacturer	AVIVA Systems Biology
Amount	100 ul
Category	Metabolism Diabetes Antibodies Immunohistochemistry Immunoprecipitation Western Blot Immunofluorescence Immunocytochemistry Primary Antibodies Immunochemistry
Type	Antibody Polyclonal
Format	Liquid
Applications	WB, IP, IHC, ICC
Specific against	Human (Homo sapiens), Pig (Porcine, Sus scrofa domesticus)
Host	Rabbit
Isotype	IgG
ECLASS 10.1	32160702
ECLASS 11.0	32160702
UNSPSC	12352203
Alias	ABC transporter,MHC 2;ABC18;ABCB3;antigen peptide transporter 2;APT2;ATP-binding cassette sub-family B member 3;ATP-binding cassette,sub-family B (MDR/TAP),member 3;D6S217E;peptide supply factor 2;peptide transporter involved in antigen processing 2;peptide transporter PSF2;Peptide transporter TAP2;PSF2;PSF-2;really interesting new gene 11 protein;RING11;transporter 2,ABC (ATP binding cassette);transporter 2,ATP-binding cassette,sub-family B (MDR/TAP).
Shipping Condition	Cool pack
Available
Manufacturer - Type	Polyclonal Antibody
Manufacturer - Category	Root Catalog/Products/Polyclonal Antibodies, Root Catalog/Products/Primary Antibodies
Shipping Temperature	Wet Ice
Molecular Weight	72 kDa
Application Data	Western blotting: 1:50-400 Immunocytochemistry in formalin fixed cells: 1:50-500 Immunohistochemistry in formalin fixed frozen section: 1:50-500 Immunohistochemistry in paraffin section: 1:10-100 Enzyme-linked Immunosorbent Assay: 1:100-1:5, 000 Optimal working dilutions must be determined by end user.
Gene symbol	TAP2
Gene Fullname	transporter 2, ATP binding cassette subfamily B member
Product format	Liquid. PBS, pH7.4, containing 0.02% NaN3, 50% glycerol.
Reconstitution and storage	2°C to 8°C\|-20°C
Description of target	Involved in the transport of antigens from the cytoplasm to the endoplasmic reticulum for association with MHC class I molecules. Also acts as a molecular scaffold for the final stage of MHC class I folding, namely the binding of peptide. Nascent MHC class I molecules associate with TAP via tapasin. Inhibited by the covalent attachment of herpes simplex virus ICP47 protein, which blocks the peptide-binding site of TAP. Inhibited by human cytomegalovirus US6 glycoprotein, which binds to the lumenal side of the TAP complex and inhibits peptide translocation by specifically blocking ATP-binding to TAP1 and prevents the conformational rearrangement of TAP induced by peptide binding. Inhibited by human adenovirus E3-19K glycoprotein, which binds the TAP complex and acts as a tapasin inhibitor, preventing MHC class I/TAP association.
Nucleotide accession_num	NM_000544
Protein accession_num	NP_000535.3
Protein name	Antigen peptide transporter 2
Clonality	Polyclonal
Purification	Affinity Purified; Protein A Purified
Immunogen	Range: Val468 - Leu686
Manufacturer - Specificity	The antibody is a rabbit polyclonal antibody raised against TAP2. It has been selected for its ability to recognize TAP2 in immunohistochemical staining and western blotting.
Formulation	PBS, pH7.4, containing 0.02% NaN3, 50% glycerol
Concentration	0.5 mg/ml

Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.

All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.

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Amount: 100 ul

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Delivery expected until 12/25/2025

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