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DAPK3 Antibody

DAPK3 Antibody

Item no.	OACD01026-1ML
Manufacturer	AVIVA Systems Biology
Amount	1 ml
Category	Oncology Neuroscience Neural Lineage Markers Neural Transcription Factors Antibodies By Cell Type Blastoma Carcinoma Glioma Hematology Leukemia Lymphoma Myeloma Melanoma Adenocarcinoma Immunohistochemistry Immunoprecipitation Western Blot ELISA Immunocytochemistry Primary Antibodies Immunochemistry
Type	Antibody Polyclonal
Format	Liquid
Applications	WB, IP, IHC, ICC
Specific against	Mouse (Murine, Mus musculus), Rat (Rattus norvegicus)
Host	Rabbit
Isotype	IgG
ECLASS 10.1	32160702
ECLASS 11.0	32160702
UNSPSC	12352203
Alias	DAP kinase 3;DAP-like kinase;death-associated kinase 3;death-associated protein kinase 3;dlk;MYPT1 kinase;ZIPK;ZIP-kinase.
Available
Manufacturer - Type	Polyclonal Antibody
Manufacturer - Category	Root Catalog/Products/Polyclonal Antibodies, Root Catalog/Products/Primary Antibodies
Molecular Weight	51 kDa
Application Data	Western blotting: 1:50-400 Immunocytochemistry in formalin fixed cells: 1:50-500 Immunohistochemistry in formalin fixed frozen section: 1:50-500 Immunohistochemistry in paraffin section: 1:10-100 Enzyme-linked Immunosorbent Assay: 1:100-1:5, 000 Optimal working dilutions must be determined by end user.
Gene symbol	Dapk3
Gene Fullname	death-associated protein kinase 3
Product format	Liquid. 0.01M PBS, pH7.4, containing 0.05% Proclin-300, 50% glycerol.
Reconstitution and storage	2°C to 8°C\|-20°C
Description of target	Serine/threonine kinase which is involved in the regulation of apoptosis, autophagy, transcription, translation and actin cytoskeleton reorganization. Regulates both type I (caspase-dependent) apoptotic and type II (caspase-independent) autophagic cell deaths signal, depending on the cellular setting. Involved in formation of promyelocytic leukemia protein nuclear body (PML-NB). Involved in apoptosis involving PAWR which mediates cytoplasmic relocation; in vitro phosphorylates PAWR (By similarity). Phosphorylates MYL12B in non-muscle cells leading to reorganization of actin cytoskeleton such as in regulation of cell polarity and cell migration. Positively regulates canonical Wnt/beta-catenin signaling through interaction with NLK and TCF7L2; disrupts the NLK-TCF7L2 complex thereby influencing the phosphorylation of TCF7L2 by NLK. Phosphorylates STAT3 and enhances its transcriptional activity. Enhances transcription from AR-responsive promoters in a hormone- and kinase-dependent manner. Phosphorylates histone H3 on 'Thr-11' at centromeres during mitosis (By similarity). Phosphorylates RPL13A on 'Ser-77' upon interferon-gamma activation which is causing RPL13A release from the ribosome, RPL13A association with the GAIT complex and its subsequent involvement in transcript-selective translation inhibition.
Nucleotide accession_num	NM_001190473
Protein accession_num	NP_001177402.1
Protein name	Death-associated protein kinase 3
Clonality	Polyclonal
Purification	Affinity Purified; Protein A Purified
Immunogen	Range: Met1 - Arg448
Manufacturer - Specificity	The antibody is a rabbit polyclonal antibody raised against DAPK3. It has been selected for its ability to recognize DAPK3 in immunohistochemical staining and western blotting.
Concentration	0.5 mg/ml

Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.

All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.

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Amount: 1 ml

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Delivery expected until 12/11/2025

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