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GSAP Antibody

GSAP Antibody

Item no.	OACD04022
Manufacturer	AVIVA Systems Biology
Amount	100 ul
Category	Oncology Neuroscience Molecular Targets for Neuroscience Aging & Neurological Disorders Protein Aggregation, Clearance & Misfolding Antibodies By Cell Type Adenocarcinoma Immunohistochemistry Immunoprecipitation Western Blot Immunocytochemistry Primary Antibodies Immunochemistry
Type	Antibody Polyclonal
Format	Liquid
Applications	WB, IP, IHC, ICC
Specific against	Human (Homo sapiens)
Host	Rabbit
Isotype	IgG
ECLASS 10.1	32160702
ECLASS 11.0	32160702
UNSPSC	12352203
Alias	gamma-secretase-activating protein;pigeon homolog;PION;protein pigeon homolog.
Shipping Condition	Cool pack
Available
Manufacturer - Type	Polyclonal Antibody
Manufacturer - Category	Root Catalog/Products/Polyclonal Antibodies, Root Catalog/Products/Primary Antibodies
Shipping Temperature	Wet Ice
Molecular Weight	29 kDa
Application Data	Western blotting: 1:50-400 Immunocytochemistry in formalin fixed cells: 1:50-500 Immunohistochemistry in formalin fixed frozen section: 1:50-500 Immunohistochemistry in paraffin section: 1:10-100 Enzyme-linked Immunosorbent Assay: 1:100-1:5, 000 Optimal working dilutions must be determined by end user.
Gene symbol	GSAP
Gene Fullname	gamma-secretase activating protein
Product format	Liquid. PBS, pH7.4, containing 0.02% NaN3, 50% glycerol.
Reconstitution and storage	2°C to 8°C\|-20°C
Description of target	Regulator of gamma-secretase activity, which specifically activates the production of amyloid-beta protein (amyloid-beta protein 40 and amyloid-beta protein 42), without affecting the cleavage of other gamma-secretase targets such has Notch. The gamma-secretase complex is an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors and APP (amyloid-beta precursor protein). Specifically promotes the gamma-cleavage of APP CTF-alpha (also named APP-CTF) by the gamma-secretase complex to generate amyloid-beta, while it reduces the epsilon-cleavage of APP CTF-alpha, leading to a low production of AICD.
Nucleotide accession_num	NM_017439
Protein accession_num	NP_059135.2
Protein name	Gamma-secretase-activating protein
Clonality	Polyclonal
Purification	Affinity Purified; Protein A Purified
Immunogen	Range: Asp616 - Leu854
Manufacturer - Specificity	The antibody is a rabbit polyclonal antibody raised against gSAP. It has been selected for its ability to recognize gSAP in immunohistochemical staining and western blotting.
Formulation	PBS, pH7.4, containing 0.02% NaN3, 50% glycerol
Concentration	0.5 mg/ml

Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.

All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.

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Amount: 100 ul

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Delivery expected until 11/13/2025

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