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SOCS3 Antibody

SOCS3 Antibody

Item no.	OACD07410
Manufacturer	AVIVA Systems Biology
Amount	100 ul
Category	Oncology Neuroscience Neural Lineage Markers Metabolism Diabetes Glucose Homeostasis Cholesterol & Lipid Metabolism Regulation of Appetite Antibodies By Cell Type Blastoma Carcinoma Hematology Leukemia Lymphoma Melanoma Obesity Myelofibrosis Immunohistochemistry Immunoprecipitation Western Blot ELISA Immunocytochemistry Enzymes Fatty Acid Synthesis Primary Antibodies Glial Cell Markers Immunochemistry
Type	Antibody Polyclonal
Format	Liquid
Applications	WB, IP, IHC, ICC
Specific against	Rat (Rattus norvegicus)
Host	Rabbit
Isotype	IgG
ECLASS 10.1	32160702
ECLASS 11.0	32160702
UNSPSC	12352203
Alias	Cish3;cytokine inducible SH2-containing protein 3;cytokine-inducible SH2 protein 3;Socs-3;Ssi-3;suppressor of cytokine signaling 3.
Shipping Condition	Cool pack
Available
Manufacturer - Type	Polyclonal Antibody
Manufacturer - Category	Root Catalog/Products/Polyclonal Antibodies, Root Catalog/Products/Primary Antibodies
Shipping Temperature	Wet Ice
Molecular Weight	25 kDa
Application Data	Western blotting: 1:50-400 Immunocytochemistry in formalin fixed cells: 1:50-500 Immunohistochemistry in formalin fixed frozen section: 1:50-500 Immunohistochemistry in paraffin section: 1:10-100 Enzyme-linked Immunosorbent Assay: 1:100-1:5, 000 Optimal working dilutions must be determined by end user.
Gene symbol	Socs3
Gene Fullname	suppressor of cytokine signaling 3
Product format	Liquid. PBS, pH7.4, containing 0.02% NaN3, 50% glycerol.
Reconstitution and storage	2°C to 8°C\|-20°C
Description of target	SOCS family proteins form part of a classical negative feedback system that regulates cytokine signal transduction. SOCS3 is involved in negative regulation of cytokines that signal through the JAK/STAT pathway. Inhibits cytokine signal transduction by binding to tyrosine kinase receptors including gp130, LIF, erythropoietin, insulin, IL12, GCSF and leptin receptors. Binding to JAK2 inhibits its kinase activity. Suppresses fetal liver erythropoiesis. Regulates onset and maintenance of allergic responses mediated by T-helper type 2 cells. Regulates IL-6 signaling in vivo. Probable substrate-recognition component of a SCF-like ECS (Elongin BC-CUL2/5-SOCS-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Seems to recognize IL6ST (By similarity).
Nucleotide accession_num	NM_053565
Protein accession_num	NP_446017.1
Protein name	Suppressor of cytokine signaling 3
Clonality	Polyclonal
Purification	Affinity Purified; Protein A Purified
Immunogen	Range: Met1 - Leu225
Manufacturer - Specificity	The antibody is a rabbit polyclonal antibody raised against SOCS3. It has been selected for its ability to recognize SOCS3 in immunohistochemical staining and western blotting.
Formulation	PBS, pH7.4, containing 0.02% NaN3, 50% glycerol
Concentration	0.5 mg/ml

Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.

All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.

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Amount: 100 ul

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Delivery expected until 10/30/2025

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