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KLRK1 Antibody

KLRK1 Antibody

Item no.	OAEE00203
Manufacturer	AVIVA Systems Biology
Amount	0.1 mg (C100)
Category	Oncology Neuroscience Neuroinflammation Metabolism Diabetes Antibodies By Cell Type Cell Biology Obesity Cell Culture Cytokines Cell Status Necrosis Apoptosis Flow Cytometry Immunohistochemistry Immunoprecipitation Primary Antibodies Functional Assays
Type	Antibody Monoclonal
Applications	FC, IP, IHC, FA
Clone	1D11
Specific against	Human (Homo sapiens)
Host	Mouse
Isotype	IgG1
Purity	> 95% (by SDS-PAGE)
Citations	Valencia J, HernÃ¡ndez-LÃ³pez C, MartÃnez VG, Hidalgo L, Zapata AG, Vicente A, Varas A, SacedÃ³n R: Transient beta-catenin stabilization modifies lineage output from human thymic CD34+CD1a- progenitors. J Leukoc Biol. 2010 Mar;87(3):405-14. Ebert LM, Meuter S, Moser B: Homing and function of human skin gammadelta T cells and NK cells: relevance for tumor surveillance. J Immunol. 2006 Apr 1;176(7):4331-6. Hasenkamp J, Borgerding A, Uhrberg M, Falk C, Chapuy B, Wulf G, Jung W, TrÃ¼mper L, Glass B: Self-tolerance of human natural killer cells lacking self-HLA-specific inhibitoryreceptors. Scand J Immunol. 2008 Mar;67(3):218-29. Sangiolo D, Martinuzzi E, Todorovic M, Vitaggio K, Vallario A, Jordaney N, Carnevale-Schianca F, Capaldi A, Geuna M, Casorzo L, Nash RA, Aglietta M, Cignetti A: Alloreactivity and anti-tumor activity segregate within two distinct subsets of cytokine-induced killer (CIK) cells: implications for their infusion across major HLA barriers. Int Immunol. 2008 Jul;20(7):841-8. Wu J, Groh V, Spies T: T cell antigen receptor engagement and specificity in the recognition of stress-inducible MHC class I-related chains by human epithelial gamma delta T cells. J Immunol. 2002 Aug 1;169(3):1236-40. Wu J, Cherwinski H, Spies T, Phillips JH, Lanier LL: DAP10 and DAP12 form distinct, but functionally cooperative, receptor complexes in natural killer cells. J Exp Med. 2000 Oct 2;192(7):1059-68. Bauer S, Groh V, Wu J, Steinle A, Phillips JH, Lanier LL, Spies T: Activation of NK cells and T cells by NKG2D, a receptor for stress-inducible MICA. Science. 1999 Jul 30;285(5428):727-9.
ECLASS 10.1	42030590
ECLASS 11.0	42030590
UNSPSC	12352203
Alias	CD314;D12S2489E;killer cell lectin-like receptor subfamily K member 1;killer cell lectin-like receptor subfamily K,member 1;KLR;NK cell receptor D;NKG2D;NKG2-D;NKG2-D type II integral membrane protein;NKG2-D-activating NK receptor.
Shipping Condition	Cool pack
Available
Manufacturer - Type	Monoclonal Antibody
Manufacturer - Applications	Flow cytometry\|Functional assay\|Immunohistochemistry-Frozen\|Immunoprecipitation
Manufacturer - Category	Root Catalog/Products/Monoclonal Antibodies, Root Catalog/Products/Primary Antibodies
Shipping Temperature	Wet Ice
Gene symbol	KLRC4-KLRK1\|KLRK1
Gene Fullname	killer cell lectin like receptor K1\|KLRC4-KLRK1 readthrough
Product format	Phosphate buffered saline (PBS), pH 7.4
Reconstitution and storage	2°C to 8°C
Description of target	Function as an activating and costimulatory receptor involved in immunosurveillance upon binding to various cellular stress-inducible ligands displayed at the surface of autologous tumor cells and virus-infected cells. Provides both stimulatory and costimulatory innate immune responses on activated killer (NK) cells, leading to cytotoxic activity. Acts as a costimulatory receptor for T-cell receptor (TCR) in CD8(+) T-cell-mediated adaptive immune responses by amplifying T-cell activation. Stimulates perforin-mediated elimination of ligand-expressing tumor cells. Signaling involves calcium influx, culminating in the expression of TNF-alpha. Participates in NK cell-mediated bone marrow graft rejection. May play a regulatory role in differentiation and survival of NK cells. Binds to ligands belonging to various subfamilies of MHC class I-related glycoproteins including MICA, MICB, RAET1E, RAET1G, RAET1L/ULBP6, ULBP1, ULBP2, ULBP3 (ULBP2>ULBP1>ULBP3) and ULBP4.
Nucleotide accession_num	NM_001199805.1; NM_007360.3
Protein accession_num	NP_001186734.1; NP_031386.2
Protein name	NKG2-D type II integral membrane protein
Clonality	Monoclonal
Purification	Purified
Immunogen	NKL cell line
Manufacturer - Specificity	The mouse monoclonal antibody 1D11 recognizes CD314 / NKG2D, a 42 kDa C-type lectin-like activating receptor expressed by NK cells, gamma/delta T cells, and CD8+ T cells.
Formulation	Azide free
Concentration	1 mg/ml
Storage Buffer	Azide free phosphate buffered saline (PBS), approx. pH 7.4; 0.2 um filter sterilized.

Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.

All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.

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Amount: 0.1 mg (C100)

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Delivery expected until 1/8/2026

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