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SELP Antibody

SELP Antibody

Item no.	OAEE00296
Manufacturer	AVIVA Systems Biology
Amount	0.1 mg (C100)
Category	Neuroscience Molecular Targets for Neuroscience Neural Signaling Neural Adhesion Molecules Antibodies Cell Biology Cell Movement Cell Adhesion Flow Cytometry Immunohistochemistry Immunoprecipitation Western Blot Immunocytochemistry Primary Antibodies Immunochemistry Functional Assays
Type	Antibody Monoclonal
Applications	WB, FC, IP, ICC, FA
Clone	AK4
Specific against	Human (Homo sapiens), Primate
Host	Mouse
Isotype	IgG1
Purity	> 95% (by SDS-PAGE)
Citations	Ludwig RJ, Schultz JE, Boehncke WH, Podda M, Tandi C, Krombach F, Baatz H, Kaufmann R, von Andrian UH, Zollner TM: Activated, not resting, platelets increase leukocyte rolling in murine skin utilizing a distinct set of adhesion molecules. J Invest Dermatol. 2004 Mar;122(3):830-6. Kowalska MA, Ratajczak J, Hoxie J, Brass LF, Gewirtz A, Poncz M, Ratajczak MZ: Megakaryocyte precursors, megakaryocytes and platelets express the HIVco-receptor CXCR4 on their surface: determination of response to stromal-derived factor-1 by megakaryocytes and platelets. Br J Haematol. 1999 Feb;104(2):220-9. Holme PA, MÃ¼ller F, Solum NO, Brosstad F, Frøland SS, Aukrust P: Enhanced activation of platelets with abnormal release of RANTES in human immunodeficiency virus type 1 infection. FASEB J. 1998 Jan;12(1):79-89. Dunlop LC, Skinner MP, Bendall LJ, Favaloro EJ, Castaldi PA, Gorman JJ, Gamble JR, Vadas MA, Berndt MC: Characterization of GMP-140 (P-selectin) as a circulating plasma protein. J Exp Med. 1992 Apr 1;175(4):1147-50.
ECLASS 10.1	42030590
ECLASS 11.0	42030590
UNSPSC	12352203
Alias	CD62;CD62 antigen-like family member P;CD62P;GMP140;GMP-140;granule membrane protein 140;granule membrane protein 140kDa;granulocyte membrane protein;GRMP;LECAM3;leukocyte-endothelial cell adhesion molecule 3;PADGEM;platelet activation dependent granule-external membrane protein;platelet alpha-granule membrane protein;PSEL;P-selectin;selectin P (granule membrane protein 140kDa,antigen CD62).
Shipping Condition	Cool pack
Available
Specificity	Human, Non-human Primate
Manufacturer - Type	Monoclonal Antibody
Manufacturer - Category	Root Catalog/Products/Monoclonal Antibodies, Root Catalog/Products/Primary Antibodies
Shipping Temperature	Wet Ice
Gene symbol	SELP
Gene Fullname	selectin P
Product format	Phosphate buffered saline (PBS), pH 7.4
Reconstitution and storage	2°C to 8°C
Description of target	Ca(2+)-dependent receptor for myeloid cells that binds to carbohydrates on neutrophils and monocytes. Mediates the interaction of activated endothelial cells or platelets with leukocytes. The ligand recognized is sialyl-Lewis X. Mediates rapid rolling of leukocyte rolling over vascular surfaces during the initial steps in inflammation through interaction with SELPLG.
Nucleotide accession_num	NM_003005.3; XM_005245435.1; XM_005245436.2
Protein accession_num	NP_002996.2; XP_005245492.1; XP_005245493.1
Protein name	P-selectin
Clonality	Monoclonal
Purification	Purified
Immunogen	Human platelets
Manufacturer - Specificity	The antibody HI62P recognizes CD62P (P-selectin), a 140 kD single chain type I transmembrane glycoprotein present in secretory alpha-granules in platelets, in Weibel-Palade bodies in endothelial cells and in megakaryocytes; it is relocated to the plasma membrane upon activation.
Formulation	Low endotoxin
Concentration	1 mg/ml
Storage Buffer	Azide free phosphate buffered saline (PBS), approx. pH 7.4; 0.2 um filter sterilized. Endotoxin level is less than 0.01 EU/ug of the protein, as determined by the LAL test.

Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.

All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.

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Amount: 0.1 mg (C100)

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