Strumpellin Antibody - C-terminal

Root Catalog/Products/Polyclonal Antibodies, Root Catalog/Products/Primary Antibodies

WASHC5

Liquid. Strumpellin Antibody is supplied in PBS containing 0.02% sodium azide.

Acts at least in part as component of the WASH core complex whose assembly at the surface of endosomes seems to inhibit WASH nucleation-promoting factor (NPF) activity in recruiting and activating the Arp2/3 complex to induce actin polymerization, and which is involved in regulation of the fission of tubules that serve as transport intermediates during endosome sorting (PubMed:19922875, PubMed:20498093). May be involved in axonal outgrowth. Involved in cellular localization of ADRB2 (PubMed:23085491). Involved in cellular trafficking of BLOC-1 complex cargos such as ATP7A and VAMP7 (PubMed:23676666).

https://www.ncbi.nlm.nih.gov/protein/NP_055661

Polyclonal

Strumpellin antibody was raised against a 19 amino acid synthetic peptide near the carboxy terminus of human Strumpellin. The immunogen is located within the last 50 amino acids of Strumpellin.