IL1B Antibody - middle region

Root Catalog/Products/Polyclonal Antibodies, Root Catalog/Products/Primary Antibodies

31 kDa

IL1B

Liquid PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

The protein encoded by this gene is a member of the interleukin 1 cytokine family. This cytokine is produced by activated macrophages as a proprotein, which is proteolytically processed to its active form by caspase 1 (CASP1/ICE). This cytokine is an important mediator of the inflammatory response, and is involved in a variety of cellular activities, including cell proliferation, differentiation, and apoptosis. The induction of cyclooxygenase-2 (PTGS2/COX2) by this cytokine in the central nervous system (CNS) is found to contribute to inflammatory pain hypersensitivity. This gene and eight other interleukin 1 family genes form a cytokine gene cluster on chromosome 2.

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

IL-1Beta Polyclonal Antibody detects endogenous levels of IL-1Beta protein.