GRIN2A Antibody (Phospho-Tyr1246/1252)

Polyclonal Antibody

Phospho-Tyr1246/1252

166 kDa

GRIN2A, GRIN2B

Liquid. 1 mg/mL in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

This gene encodes a member of the glutamate-gated ion channel protein family. The encoded protein is an N-methyl-D-aspartate (NMDA) receptor subunit. NMDA receptors are both ligand-gated and voltage-dependent, and are involved in long-term potentiation, an activity-dependent increase in the efficiency of synaptic transmission thought to underlie certain kinds of memory and learning. These receptors are permeable to calcium ions, and activation results in a calcium influx into post-synaptic cells, which results in the activation of several signaling cascades. Disruption of this gene is associated with focal epilepsy and speech disorder with or without mental retardation. Alternative splicing results in multiple transcript variants.

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Phospho-NMDAEpsilon1/2 (Tyr1246/1252) Polyclonal Antibody detects endogenous levels of NMDAEpsilon1/2 protein only when phosphorylated at Y1246/1252.