PDGFRB Antibody (Phospho-Tyr751)

Polyclonal Antibody

Phospho-Tyr751

124 kDa

PDGFRB

Liquid. PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

This gene encodes a cell surface tyrosine kinase receptor for members of the platelet-derived growth factor family. These growth factors are mitogens for cells of mesenchymal origin. The identity of the growth factor bound to a receptor monomer determines whether the functional receptor is a homodimer or a heterodimer, composed of both platelet-derived growth factor receptor alpha and beta polypeptides. This gene is flanked on chromosome 5 by the genes for granulocyte-macrophage colony-stimulating factor and macrophage-colony stimulating factor receptor; all three genes may be implicated in the 5-q syndrome. A translocation between chromosomes 5 and 12, that fuses this gene to that of the translocation, ETV6, leukemia gene, results in chronic myeloproliferative disorder with eosinophilia.

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Phospho-PDGFR-Beta (Tyr751) Polyclonal Antibody detects endogenous levels of PDGFR-Beta protein only when phosphorylated at Y751.