PIM1 Antibody (Phospho-Tyr309)

Polyclonal Antibody

Phospho-Tyr309

45 kDa

PIM1

Liquid PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

The protein encoded by this gene belongs to the Ser/Thr protein kinase family, and PIM subfamily. This gene is expressed primarily in B-lymphoid and myeloid cell lines, and is overexpressed in hematopoietic malignancies and in prostate cancer. It plays a role in signal transduction in blood cells, contributing to both cell proliferation and survival, and thus provides a selective advantage in tumorigenesis. Both the human and orthologous mouse genes have been reported to encode two isoforms (with preferential cellular localization) resulting from the use of alternative in-frame translation initiation codons, the upstream non-AUG (CUG) and downstream AUG codons (PMIDs:16186805, 1825810).

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Phospho-Pim-1 (Tyr309) Polyclonal Antibody detects endogenous levels of Pim-1 protein only when phosphorylated at Y309.