SPTAN1 Antibody (Cleaved-Asp1185)

Polyclonal Antibody

Cleaved-Asp1185

137 kDa

SPTAN1

Liquid PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Spectrins are a family of filamentous cytoskeletal proteins that function as essential scaffold proteins that stabilize the plasma membrane and organize intracellular organelles. Spectrins are composed of alpha and beta dimers that associate to form tetramers linked in a head-to-head arrangement. This gene encodes an alpha spectrin that is specifically expressed in nonerythrocytic cells. The encoded protein has been implicated in other cellular functions including DNA repair and cell cycle regulation. Mutations in this gene are the cause of early infantile epileptic encephalopathy-5. Alternate splicing results in multiple transcript variants.

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Cleaved-Spectrin Alpha II (D1185) Polyclonal Antibody detects endogenous levels of fragment of activated Spectrin Alpha II protein resulting from cleavage adjacent to D1185.