TIRAP Antibody (Phospho-Tyr86)

Polyclonal Antibody

Phospho-Tyr86

33/30 kDa

TIRAP

Liquid. PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

The innate immune system recognizes microbial pathogens through Toll-like receptors (TLRs), which identify pathogen-associated molecular patterns. Different TLRs recognize different pathogen-associated molecular patterns and all TLRs have a Toll-interleukin 1 receptor (TIR) domain, which is responsible for signal transduction. The protein encoded by this gene is a TIR adaptor protein involved in the TLR4 signaling pathway of the immune system. It activates NF-kappa-B, MAPK1, MAPK3 and JNK, which then results in cytokine secretion and the inflammatory response. Alternative splicing of this gene results in several transcript variants; however, not all variants have been fully described.

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Phospho-TIRAP (Tyr86) Polyclonal Antibody detects endogenous levels of TIRAP protein only when phosphorylated at Y86.