MED12 Antibody - middle region

Root Catalog/Products/Polyclonal Antibodies, Root Catalog/Products/Primary Antibodies

247 kDa

MED12

Liquid PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. This subunit may specifically regulate transcription of targets of the Wnt signaling pathway and SHH signaling pathway.

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

TRAP230 Polyclonal Antibody detects endogenous levels of TRAP230 protein.