ATP6V1B1 Antibody - C-terminal region

Polyclonal Antibody

Wet Ice

ATP6V1B1

Liquid PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

V-ATPase B1 is a protein encoded by the ATP6V1B1 gene which is approximately 56.8 kDa. V-ATPase B1 is localised to the endomembrane system. It is involved in insulin receptor recycling, innate immune system, metabolism and mTOR signalling pathway. It mediates acidification of eukaryotic intracellular organelles. V-ATPase dependent organelle acidification is necessary for such intracellular processes as protein sorting, zymogen activation, receptor-mediated endocytosis and synaptic vesicle proton gradient generation. V-ATPase B1 is expressed in the cochlea and endolymphatic sac. Mutations in the ATP6V1B1 gene may result in renal tubular acidosis with progressive nerve deafness.

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

V-ATPase B1 Polyclonal Antibody detects endogenous levels of V-ATPase B1 protein.