PTPN11 Antibody, KO Validated

Blue Ice

Observed: 75kDa

The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP contains two tandem Src homology-2 domains, which function as phospho-tyrosine binding domains and mediate the interaction of this PTP with its substrates. This PTP is widely expressed in most tissues and plays a regulatory role in various cell signaling events that are important for a diversity of cell functions, such as mitogenic activation, metabolic control, transcription regulation, and cell migration. Mutations in this gene are a cause of Noonan syndrome as well as acute myeloid leukemia. Two transcript variants encoding different isoforms have been found for this gene.

KO

Affinity purification

U-87MG

A-431

Mouse brain

batch dependent

WB: 1:500 - 1:2000
IF: 1:50 - 1:200

Polyclonal

Homo sapiens

Antibody is Knockout validated.