IL1B Antibody

Blue Ice

Observed: 17kDa, 31kDa

The protein encoded by this gene is a member of the interleukin 1 cytokine family. This cytokine is produced by activated macrophages as a proprotein, which is proteolytically processed to its active form by caspase 1 (CASP1/ICE). This cytokine is an important mediator of the inflammatory response, and is involved in a variety of cellular activities, including cell proliferation, differentiation, and apoptosis. The induction of cyclooxygenase-2 (PTGS2/COX2) by this cytokine in the central nervous system (CNS) is found to contribute to inflammatory pain hypersensitivity. This gene and eight other interleukin 1 family genes form a cytokine gene cluster on chromosome 2.

None

THP-1

A549

Mouse lung

PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

A synthetic peptide of human IL1B

interleukin 1, beta

Optimal dilutions for each application to be determined by the researcher.