DNMT1 Antibody

Blue Ice

Observed: 200kDa

This gene encodes an enzyme that transfers methyl groups to cytosine nucleotides of genomic DNA. This protein is the major enzyme responsible for maintaining methylation patterns following DNA replication and shows a preference for hemi-methylated DNA. Methylation of DNA is an important component of mammalian epigenetic gene regulation. Aberrant methylation patterns are found in human tumors and associated with developmental abnormalities. Variation in this gene has been associated with cerebellar ataxia, deafness, and narcolepsy, and neuropathy, hereditary sensory, type IE. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2016]

None

HeLa

SW480

PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

Recombinant fusion protein of Human DNMT1.

DNA (cytosine-5-)-methyltransferase 1

Optimal dilutions for each application to be determined by the researcher.