APEX1 Antibody, KO Validated

Blue Ice

Observed: 39kDa

Apurinic/apyrimidinic (AP) sites occur frequently in DNA molecules by spontaneous hydrolysis, by DNA damaging agents or by DNA glycosylases that remove specific abnormal bases. AP sites are pre-mutagenic lesions that can prevent normal DNA replication so the cell contains systems to identify and repair such sites. Class II AP endonucleases cleave the phosphodiester backbone 5' to the AP site. This gene encodes the major AP endonuclease in human cells. Splice variants have been found for this gene; all encode the same protein.

KO

Affinity purification

HeLa

batch dependent

WB: 1:500 - 1:2000
IF: 1:50 - 1:100
IP: 1:50 - 1:200

Polyclonal

Homo sapiens

Antibody is Knockout validated.