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FADD Antibody

FADD Antibody

Item no.	PRS-19-878-100uL
Manufacturer	ProSci
Amount	100 uL
Quantity options	100 uL
Category	Oncology Antibodies By Cell Type Carcinoma Cell Biology Cell Status Apoptosis Immunohistochemistry Immunoprecipitation Western Blot Primary Antibodies
Type	Antibody Primary
Format	Liquid
Applications	WB, IP, IHC
Specific against	Human (Homo sapiens), Mouse (Murine, Mus musculus), Rat (Rattus norvegicus)
Host	Rabbit
Isotype	IgG
Conjugate/Tag	Unconjugated
NCBI	FADD
ECLASS 10.1	32160702
ECLASS 11.0	32160702
UNSPSC	12352203
Alias	FADD,GIG3,MORT1
Shipping Condition	Cool pack
Available
Specificity	Human,Mouse,Rat
Manufacturer - Type	Primary Antibodies
Shipping Temperature	Blue Ice
Storage Conditions	Store at -20˚ C. Avoid freeze / thaw cycles.
Molecular Weight	Observed: 26kDa
Manufacturer - Research Area	Apoptosis, Cancer, Cell Cycle, Immunology, Neuroscience, Inflammasomes
Background	The protein encoded by this gene is an adaptor molecule that interacts with various cell surface receptors and mediates cell apoptotic signals. Through its C-terminal death domain, this protein can be recruited by TNFRSF6/Fas-receptor, tumor necrosis factor receptor, TNFRSF25, and TNFSF10/TRAIL-receptor, and thus it participates in the death signaling initiated by these receptors. Interaction of this protein with the receptors unmasks the N-terminal effector domain of this protein, which allows it to recruit caspase-8, and thereby activate the cysteine protease cascade. Knockout studies in mice also suggest the importance of this protein in early T cell development.
By Type	Apoptosis, Cancer, Cell Cycle, Immunology, Neuroscience, Inflammasomes
Modifications	None
Purification	Affinity purification
Positive Control 1	293T
Positive Control 2	MCF7
Positive Control 3	HeLa
Positive Control 4	Mouse liver
Positive Control 5	Mouse kidney
Positive Control 6	Mouse heart
Concentration	batch dependent
Buffer	PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Application Note	WB: 1:500 - 1:2000 IHC: 1:50 - 1:200 IP: 1:50 - 1:200
Immunogen	Recombinant fusion protein containing a sequence corresponding to amino acids 1-208 of human FADD (NP_003815.1).
Clonality	Polyclonal
NCBI Official Name	Fas (TNFRSF6)-associated via death domain
NCBI Organism	Homo sapiens
User Note	Optimal dilutions for each application to be determined by the researcher.

Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.

All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.

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Amount: 100 uL

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Delivery expected until 12/4/2025

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