SNRNP200 Antibody

Blue Ice

Observed: 244kDa

Pre-mRNA splicing is catalyzed by the spliceosome, a complex of specialized RNA and protein subunits that removes introns from a transcribed pre-mRNA segment. The spliceosome consists of small nuclear RNA proteins (snRNPs) U1, U2, U4, U5 and U6, together with approximately 80 conserved proteins. U5 snRNP contains nine specific proteins. This gene encodes one of the U5 snRNP-specific proteins. This protein belongs to the DEXH-box family of putative RNA helicases. It is a core component of U4/U6-U5 snRNPs and appears to catalyze an ATP-dependent unwinding of U4/U6 RNA duplices. Mutations in this gene cause autosomal-dominant retinitis pigmentosa. Alternatively spliced transcript variants encoding different isoforms have been found, but the full-length nature of these variants has not been determined.

None

Jurkat

HepG2

PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

Recombinant fusion protein containing a sequence corresponding to amino acids 1947-2136 of human SNRNP200 (NP_054733.2).

small nuclear ribonucleoprotein U5 subunit 200

Optimal dilutions for each application to be determined by the researcher.