CHEK1 Antibody

Blue Ice

Observed: 54kDa

The protein encoded by this gene belongs to the Ser/Thr protein kinase family. It is required for checkpoint mediated cell cycle arrest in response to DNA damage or the presence of unreplicated DNA. This protein acts to integrate signals from ATM and ATR, two cell cycle proteins involved in DNA damage responses, that also associate with chromatin in meiotic prophase I. Phosphorylation of CDC25A protein phosphatase by this protein is required for cells to delay cell cycle progression in response to double-strand DNA breaks. Several alternatively spliced transcript variants have been found for this gene.

None

SW620

Mouse thymus

Rat testis

PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

A synthetic peptide of human CHEK1

checkpoint kinase 1

Optimal dilutions for each application to be determined by the researcher.