Anti-CD99 Rabbit mAb

Primary Antibodies

Uncategorized

Ambient temperature

Stable for 12 months from date of receipt/reconstitution.

CD99 is a 32kDa transmembrane glycoprotein encoded by the MIC2 gene, which participates in many cell functions such as cell adhesion and migration, endocytosis and exocytosis, and intracellular protein transport. CD99 is mainly expressed in bone marrow pre-B cells, neutrophils, monocytes, thymic cortical T lymphocytes, ovarian granulosa cells, ependymal cells of the central nervous system, and supporting testicular cells. CD99 plays a role in the late stage of leukocyte extravasation, helping leukocytes to overcome endothelial basement membrane. Due to selective cleavage, CD99 produces two isoforms with different carboxyl ends: CD99 type I (CD99wt) is a full-length form containing 185 amino acids, while CD99 type II (CD99sh) contains 161 amino acids. Their expression regulation is different, and may have opposite functions in different environments. CD99 is expressed in many types of tumor cells and is used in the differential diagnosis of Ewing's sarcoma.

PBS, Glycerol, BSA

Recombinant Monoclonal

Cell membrane, cytoplasm