Raly (RNA-Binding Protein Raly, Autoantigen p542, Heterogeneous Nuclear Ribonucleoprotein C-like 2, hnRNP Core Protein C-like 2, hnRNP Associated with lethal yellow Protein Homolog, RALY, HNRPCL2, P542)

Antibodies / Antibodies-Nuclear Proteins

-20°C

Supplied as a liquid PBS, 0.05% sodium azide, pH 7.2.

Synthetic peptide corresponding to amino acids 70-120 of Human Raly.

Raly, also known as hnRNP associated with lethal yellow homolog, autoantigen p542 or heterogeneous nuclear ribonucleoprotein C-like 2 (hnRNPCL2), is a 306 amino acid protein belonging to the RRM HNRPC family. Localized to the nucleus, Raly is thought to be an RNA-binding protein involved in pre-mRNA splicing. Phosphorylated upon DNA damage, Raly has been found to be a subunit of the spliceosome C complex. Raly is also an autoantigen that is crossreactive with an Epstein-Barr virus protein. Raly is expressed at higher levels in pancreas, liver, skeletal muscle, lung, brain, heart and kidney with lower levels found in placenta. Produced by alternative splicing, Raly is expressed as two isoforms.

Applications:
Suitable for use in Western Blot. Other applications not tested.

Recommended Dilution:
Western Blot: 1:500-1:1000
Optimal dilutions to be determined by the researcher.

Storage and Stability:
May be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for 12 months after receipt. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.