RNPC3 (RNA-Binding Protein 40, RNA-Binding Motif Protein 40, RNA-Binding region-Containing Protein 3, U11/U12 Small Nuclear Ribonucleoprotein 65kD Protein, U11/U12 snRNP 65kD Protein, U11/U12-65K, RNPC3, KIAA1839, R

Antibodies / Antibodies-Binding Proteins

-20°C

Supplied as a liquid PBS,  0.1% sodium azide,  50% glycerol.

Recombinant full length Human RNPC3.

U11/U12 snRNP 65K, also known as RBM40 (RNA-binding protein 40), RNPC3 (RNA-binding region-containing protein 3) or RNP, is a 517 amino acid nuclear protein that plays a role in pre-mRNA U12-dependent splicing by the minor spliceosome, ultimately leading to the removal of U12-type introns. Expressed at highest levels in kidney and pancreas, U11/U12 snRNP 65K is also weakly detected in placenta, heart, brain, lung, liver, thymus, colon, ovary, testis, prostate, spleen and small intestine. The gene encoding U11/U12 snRNP 65K maps to human chromosome 1, which spans 260 million base pairs, contains over 3, 000 genes and comprises nearly 8% of the human genome. Chromosome 1 houses a large number of disease-associated genes, including those that are involved in familial adenomatous polyposis, Stickler syndrome, Parkinson’s disease, Gaucher disease, schizophrenia and Usher syndrome.

Applications:
Suitable for use in Western Blot, Immunohistochemistry. Other applications not tested.

Recommended Dilution:
Western Blot: 1:500-1:2000
Immunohistochemistry: 1:50-1:200
Optimal dilutions to be determined by the researcher.

Storage and Stability:
May be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for 12 months after receipt. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.