TAUT (MGC10619, MGC131729, OTTHUMP00000208177, OTTHUMP00000208180, SC6A6, SLC6A6, Sodium- and chloride-Dependent taurine Transporter, Solute Carrier Family 6 (neurotransmitter Transporter, taurine), Member 6, Solute Carrier Family 6 Member 6, TA

Antibodies / Antibodies-Transport Proteins

-20°C

Supplied as a liquid PBS, 0.05% sodium azide, pH 7.2.

Synthetic peptide corresponding to amino acids 570-620 of Human TAUT.

Taurine is an abundant organic osmolyte that possesses antioxidant and immunomodulatory properties and plays a role in cell volume homeostasis. Taurine is taken up into cells via the taurine transporter (TAUT). TAUT, which is sodium- and chloride-dependent, is a multi-pass membrane protein belonging to the sodium neurotransmitter symporter (SNF) family of proteins. TNFalpha upregulates TAUT expression, while phosphorylation on Serine 322 downregulates it. Overexpression of TAUT protects renal cells from cisplatin-induced nephrotoxicity.

Applications:
Suitable for use in Western Blot, Immunohistochemistry. Other applications not tested.

Recommended Dilution:
Western Blot: 1:500-1:1000
Immunohistochemistry: 1:50-1:200
Optimal dilutions to be determined by the researcher.

Storage and Stability:
May be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for 12 months after receipt. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.