Ki 67

Antibodies / Antibodies-Cancer Markers

-20°C

Supplied as a liquid in PBS, pH 7.2, 0.5% BSA, 0.02% sodium azide, 50% glycerol.

Synthetic peptide corresponding to human Ki 67 (P46013).

Ki 67 is a protein encoded by the MKI67 gene which is ~358.6kD. Ki 67 is localized to the nucleus. It is involved in DNA damage, neuroscience and primary focal segmental glomerulosclerosis. It is required to maintain individual mitotic chromosomes dispersed in the cytoplasm following nuclear envelope disassembly. It associates with the surface of the mitotic chromosome and covers a substantial fraction of the chromosome surface. Ki 67 is expressed in the intestine, liver, blood, lung and lymph nodes. Mutations in the MKI67 gene may result in brain ependymoma.

Applications:
Suitable for use in Immunohistochemistry. Other applications not tested.

Recommended Dilutions:
Immunohistochemistry: 1:200
Optimal dilutions to be determined by the researcher.

Storage and Stability:
May be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for 12 months after receipt. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.