TRAF3IP2 (Adapter Protein CIKS, Connection to IKK and SAPK/JNK, Nuclear Factor NF-kappa-B Activator 1, ACT1, TRAF3-Interacting Protein 2, C6orf2, C6orf4, C6orf5, C6orf6)

Antibodies / Antibodies-Transcription Factors

-20°C

Supplied as a liquid in PBS, 0.09% sodium azide, 50% glycerol.

Recombinant protein corresponding to human TRAF3IP2.

Members of the NFkB family of transcription factors are important in regulating the expression of various cellular and viral genes involved in immune and inflammatory responses, cell survival and stress responses. IL-1, TNFa and other related signaling pathways activate transcription factors through the activation of JNK. The NFkB signaling pathway converges with the signal-induced activation of JNK upstream of IKK. Isolated from the human embryonic kidney (HEK) 293 cell line, Act1 is an IKKg-associated protein that activates both NFkB and JNK constitutively. Act1, also designated NFkB activator 1 or CIKS (for connection to IKK and SAPK/JNK), may function as a coordinator between two stress-induced signaling pathways.

Applications:
Suitable for use in Western Blot, Immunohistochemistry. Other applications not tested.

Recommended Dilution:
Western Blot: 1:500-1:2000
Immunohistochemistry: 1:50-1:200
Optimal dilutions to be determined by the researcher.

Storage and Stability:
May be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for 12 months after receipt. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.