ZCCHC17 (Nucleolar Protein of 40kD, pNO40, Pnn-Interacting Nucleolar Protein, Putative S1 RNA-binding Domain Protein, PS1D Protein, Zinc Finger CCHC Domain-containing Protein 17, PS1D)

Antibodies / Antibodies-Transcription Factors, Zinc (Ring) Finger

-20°C

Supplied as a liquid in PBS, pH 7.3, 0.05% sodium azide.

Synthetic peptide corresponding to human ZCCHC17.

Zinc-finger proteins contain DNA-binding domains and have a wide variety of functions, most of which encompass some form of transcriptional activation or repression. ZCCHC17 (zinc finger, CCHC domain containing 17), also known as PS1D (putative S1 RNA-binding domain protein), Pnn (Pinin)-interacting nucleolar protein or pNO40, is a 241aa protein that associates with both Pinin and the 60S ribosomal subunit. Localizing to nucleolus, ZCCHC17 is ubiquitously expressed and has been suggested to play a role in ribosome maturation and biogenesis. ZCCHC17 contains one CCHC-type zinc finger, a S1 motif domain and exists as two alternatively spliced isoforms that map to human chromosome 1p35.2. Human chromosome 1 spans 260 million base pairs, contains over 3, 000 genes, comprises nearly 8% of the human genome and houses a large number of disease-associated genes, including those that are involved in Stickler syndrome, Parkinson’s disease, Gaucher disease and Usher syndrome.

Applications:
Suitable for use in Western Blot. Other applications not tested.

Recommended Dilution:
Western Blot: 1:500-1:1000
Optimal dilutions to be determined by the researcher.

Storage and Stability:
May be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for 12 months after receipt. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.