TREM-1 (CD354, Triggering Receptor Expressed on Myeloid Cells 1, Triggering Receptor Expressed on Monocytes 1)

Mab

IgG2b, k

-20°C

Supplied as a liquid in PBS, pH 7.2, 0.09% sodium azide.

Recombinant human TREM-1.

TREM-1 is a 30kD glycoprotein also known as triggering receptor expressed on myeloid cells 1, and triggering receptor expressed on monocytes 1. It is a Type I membrane protein that contains an immunoglobulin-like V-type domain. Alternatively spliced protein variant may be secreted. TREM-1 is highly expressed on peripheral blood myeloid cells (particularly mature monocytes and granulocytes); TREM-1 expression can be further upregulated by bacteria, fungi and lipopolysaccharide. TREM-1 has been shown to interact with the adaptor protein DAP12 to stimulate neutrophil and monocyte-mediated inflammatory responses through the triggering and release of pro-inflammatory cytokines and chemokines. TREM-1 is thought to amplify inflammatory responses to fungal and bacterial infections and potentiate septic shock.

Applications:
Suitable for use in ELISA, Flow Cytometry and Western Blot. Other applications not tested.

Recommended Dilution:
Flow Cytometry: ≤0.5ug/10e6 cells in 100ul
Optimal dilutions to be determined by the researcher.

Storage and Stability:
May be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for 12 months after receipt. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.