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Goat Anti-CACNB4 (internal) Antibody

Goat Anti-CACNB4 (internal) Antibody

Manufacturer	Abcepta
Category	Antibodies Primary Antibodies
Type	Antibody Primary
Specific against	other
Applications	WB, ELISA
Amount	100 ug
Host	Goat
Item no.	ABC-AF1177b
eClass 6.1	32160702
eClass 9.0	32160702
Available
Primary Accession	O00305
Antigen Type	Synthetic Peptide
Application	WB, E
Bio Background	This gene encodes a member of the beta subunit family of voltage-dependent calcium channel complex proteins. Calcium channels mediate the influx of calcium ions into the cell upon membrane polarization and consist of a complex of alpha-1, alpha-2/delta, beta, and gamma subunits in a 1:1:1:1 ratio. Various versions of each of these subunits exist, either expressed from similar genes or the result of alternative splicing. The protein encoded by this locus plays an important role in calcium channel function by modulating G protein inhibition, increasing peak calcium current, controlling the alpha-1 subunit membrane targeting and shifting the voltage dependence of activation and inactivation. Certain mutations in this gene have been associated with idiopathic generalized epilepsy (IGE) and juvenile myoclonic epilepsy (JME). Multiple transcript variants encoding different isoforms have been found for this gene.
Bio References	Replication of previous genome-wide association studies of bone mineral density in premenopausal American women. Ichikawa S, et al. J Bone Miner Res, 2010 Aug. PMID 20200978. Identification of SH3 domain interaction partners of human FasL (CD178) by phage display screening. Voss M, et al. BMC Immunol, 2009 Oct 6. PMID 19807924. A CACNB4 mutation shows that altered Ca(v)2.1 function may be a genetic modifier of severe myoclonic epilepsy in infancy. Ohmori I, et al. Neurobiol Dis, 2008 Dec. PMID 18755274. [Physiological role of presynaptic Ca2+ channel complexes on neurotransmitter release] Kiyonaka S, et al. Seikagaku, 2008 Jul. PMID 18712068. Episodic ataxia: SLC1A3 and CACNB4 do not explain the apparent genetic heterogeneity. Graves TD, et al. J Neurol, 2008 Jul. PMID 18446307.
Clonality	Polyclonal
Gene ID	785
Gene Name	CACNB4 (HGNC:1404)
Subtitle	Peptide-affinity purified goat antibody
Reactivity	H
Legend image 1	AF1177b (0.2 µg/ml) staining of Human Bone Marrow lysate (35 µg protein in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence.
Type image 1	WB
Other Accession	NP_001005746; 785; 12298 (mouse); 58942 (rat);
Predicted	M, Rat, Dog
Concentration (mg/ml)	100ug/200ul

Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.

All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.

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ABC-AF1177b-datasheet.pdf

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Amount: 100 ug

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Delivery expected until 7/4/2024