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SMURF2 Antibody

SMURF2 Antibody

Item no.	ABC-AM8633b
Manufacturer	Abcepta
Amount	200 ul
Category	Antibodies Cell Biology Cell Status Western Blot Senescence Primary Antibodies
Type	Antibody Monoclonal
Applications	WB
Clone	1826CT865.51.28
Specific against	Human (Homo sapiens)
Host	Mouse
Isotype	IgG1 Kappa
Citations	Kavsak P.,et al.Mol. Cell 6:1365-1375(2000). Lin X.,et al.J. Biol. Chem. 275:36818-36822(2000). Zhang Y.,et al.Proc. Natl. Acad. Sci. U.S.A. 98:974-979(2001). Bonni S.,et al.Nat. Cell Biol. 3:587-595(2001). Di Guglielmo G.M.,et al.Nat. Cell Biol. 5:410-421(2003).
ECLASS 10.1	42030590
ECLASS 11.0	42030590
UNSPSC	12352203
Alias	E3 ubiquitin-protein ligase SMURF2,hSMURF2,6.3.2.-,SMAD ubiquitination regulatory factor 2,SMAD-specific E3 ubiquitin-protein ligase 2,SMURF2
Similar products	SMURF2, E3 ubiquitin-protein ligase SMURF2, SMAD ubiquitination regulatory factor 2, SMAD-specific E3 ubiquitin-protein ligase 2, hSMURF2, 6.3.2.-
Available
Manufacturer - Category	Crown Antibodies; Primary Antibodies; Stem Cells; SARS-Human interaction partners
Manufacturer - Targets	This SMURF2 antibody is generated from a mouse immunized with a recombinant protein of human SMURF2.
Bio Background	E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. Interacts with SMAD1 and SMAD7 in order to trigger their ubiquitination and proteasome-dependent degradation. In addition, interaction with SMAD7 activates autocatalytic degradation, which is prevented by interaction with SCYE1. Forms a stable complex with the TGF-beta receptor-mediated phosphorylated SMAD2 and SMAD3. In this way, SMAD2 may recruit substrates, such as SNON, for ubiquitin-mediated degradation. Enhances the inhibitory activity of SMAD7 and reduces the transcriptional activity of SMAD2. Coexpression of SMURF2 with SMAD1 results in considerable decrease in steady-state level of SMAD1 protein and a smaller decrease of SMAD2 level.
Clonality	Monoclonal
Gene Name	SMURF2
Subtitle	Purified Mouse Monoclonal Antibody (Mab)
Reactivity	H
Calculated Molecular Weight	86196
Antigen Source	HUMAN
Formulation	Purified monoclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein G column, followed by dialysis against PBS.
Dilution	WB: 1:2000-1:4000
Antigen Type	Recombinant Protein

Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.

All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.

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Amount: 200 ul

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Delivery expected until 1/1/2026

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