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SILV Antibody (Center)

SILV Antibody (Center)

Item no.	ABC-AP13753c-ev
Manufacturer	Abcepta
Amount	80 ul
Category	Antibodies Primary Antibodies
Type	Antibody Primary
Format	Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
Applications	WB
Specific against	other
Host	Rabbit
ECLASS 10.1	32160702
ECLASS 11.0	32160702
UNSPSC	12352203
Similar products	SILV, PMEL, D12S53E, PMEL17, Melanocyte protein PMEL, ME20-M, Melanocyte protein Pmel 17, Melanocytes lineage-specific antigen GP100, Melanoma-associated ME20 antigen, P1, P100, Premelanosome protein, Silver locus protein homolog, M-alpha, P26, ME20M, 95 kDa melanocyte-specific secreted glycoprotein, Secreted melanoma-associated ME20 antigen, ME20-S, ME20S, M-beta
Available
Primary Accession	P40967
Antigen Type	Synthetic Peptide
Application	WB
Bio Background	SILV plays a central role in the biogenesis of melanosomes. Involved in the maturation of melanosomes from stage I to II. The transition from stage I melanosomes to stage II melanosomes involves an elongation of the vesicle, and the appearance within of distinct fibrillar structures. Release of the soluble form, ME20-S, could protect tumor cells from antibody mediated immunity.
Bio References	Leonhardt, R.M., et al. J. Biol. Chem. 285(21):16166-16183(2010) Hoashi, T., et al. FASEB J. 24(3):916-930(2010) Watt, B., et al. J. Biol. Chem. 284(51):35543-35555(2009) McGlinchey, R.P., et al. Proc. Natl. Acad. Sci. U.S.A. 106(33):13731-13736(2009) Kummer, M.P., et al. J. Biol. Chem. 284(4):2296-2306(2009)
Clonality	Polyclonal
Clone/Animal Names	RB33755
Gene ID	6490
Gene Name	PMEL
Subtitle	Affinity Purified Rabbit Polyclonal Antibody (Pab)
Reactivity	H
Legend image 1	SILV Antibody (Center) (Cat. #AP13753c) western blot analysis in CEM cell line lysates (35ug/lane).This demonstrates the SILV antibody detected the SILV protein (arrow).
Type image 1	WB
Dilution image 1	1:1000
Other Accession	NP_008859.1
Isotype	Rabbit Ig
Calculated MW	70255
Antigen Region	412-440
Antigen Source	HUMAN
Target/Specificity	This SILV antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 412-440 amino acids from the Central region of human SILV.
NCBI Accession	NP_001186982.1; NP_001186983.1; NP_008859.1

Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.

All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.

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Amount: 80 ul

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Delivery expected until 9/4/2025

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